709 results found
    1. Cell Biology
    2. Microbiology and Infectious Disease

    ISG15 counteracts Listeria monocytogenes infection

    Lilliana Radoshevich, Francis Impens ... Pascale Cossart
    The induction of ISG15 during bacterial infection can be independent of Type I Interferons and leads to an increase in the secretion of cytokines known to be critical for bacterial clearance.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Population scale mapping of transposable element diversity reveals links to gene regulation and epigenomic variation

    Tim Stuart, Steven R Eichten ... Ryan Lister
    Fine mapping of transposable element presence/absence variation amongst 216 Arabidopsis strains uncovers widespread novel genetic diversity that underlies differences in transcription and DNA methylation patterns.
    1. Genetics and Genomics
    2. Plant Biology

    Stress induced gene expression drives transient DNA methylation changes at adjacent repetitive elements

    David Secco, Chuang Wang ... Ryan Lister
    Phosphate starvation in rice induces widespread, but transient, modulation of DNA methylation near stress responsive genes that is independent from the RNA-directed DNA methylation pathway.
    1. Neuroscience

    Cortical activity during naturalistic music listening reflects short-range predictions based on long-term experience

    Pius Kern, Micha Heilbron ... Eelke Spaak
    When a person listens to music, their brain continually predicts upcoming notes, based on that person's likely lifelong musical experience.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Listeria monocytogenes cell-to-cell spread in epithelia is heterogeneous and dominated by rare pioneer bacteria

    Fabian E Ortega, Elena F Koslover, Julie A Theriot
    The pathogenic bacterium Listeria monocytogenes spreads infection using a two-tiered strategy, where most bacteria spread locally but a few 'pioneers' move further, increasing the likelihood of a persistent infection.
    1. Neuroscience

    Brain clusterin protein isoforms and mitochondrial localization

    Sarah K Herring, Hee-Jung Moon ... Liqin Zhao
    Identification and characterization of multiple brain clusterin isoforms, including a mitochondrial matrix-targeted isoform, provides foundation to potentially clarify the link between these proteins and the development of late-onset Alzheimer’s disease.
    1. Microbiology and Infectious Disease

    4-Hydroxy-2-nonenal antimicrobial toxicity is neutralized by an intracellular pathogen

    Hannah Tabakh, Adelle P McFarland ... Joshua J Woodward
    The aldehyde 4-hydroxy-2-nonenal is a novel component of the host antimicrobial reactive oxygen burst, and the bacterium Listeria monocytogenes encodes genes specifically for its detoxification.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Listeria monocytogenes requires cellular respiration for NAD+ regeneration and pathogenesis

    Rafael Rivera-Lugo, David Deng ... Samuel H Light
    The bacterial pathogen Listeria monocytogenes requires respiration for the maintenance of cellular redox homeostasis.
    1. Neuroscience

    Distinct modes of endocytotic presynaptic membrane and protein uptake at the calyx of Held terminal of rats and mice

    Yuji Okamoto, Noa Lipstein ... Mitsuharu Midorikawa
    Capacitance measurements and pH imaging reveal distinct modes of uptake for endocytotic presynaptic membrane and proteins.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection

    Donna A MacDuff, Tiffany A Reese ... Herbert W Virgin
    HOIL-1 deficiency in mice results in a severe immunodeficiency that is effectively complemented by chronic infection with a murine gamma-herpesvirus.

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