8,199 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Mesoscale cortex-wide neural dynamics predict self-initiated actions in mice several seconds prior to movement

    Catalin Mitelut, Yongxu Zhang ... Timothy H Murphy
    Mouse self-initiated behaviors can be identified seconds prior to action and have similar neuro-dynamical structure to neural dynamics underlying human voluntary actions supporting the use of mouse models in self-initiated and volitional action research.
    1. Cell Biology
    2. Plant Biology

    The Arabidopsis SAC9 enzyme is enriched in a cortical population of early endosomes and restricts PI(4,5)P2 at the plasma membrane

    Alexis Lebecq, Mehdi Doumane ... Marie-Cécile Caillaud
    SAC9 prevents the accumulation of PI(4,5)P2 in intracellular compartments, thereby contributing to clathrin-mediated endocytosis at the plasma membrane and regulating the cortical localization of its protein partner SH3P2.
    1. Microbiology and Infectious Disease

    Small RNAs from mitochondrial genome recombination sites are incorporated into T. gondii mitoribosomes

    Sabrina Tetzlaff, Arne Hillebrand ... Christian Schmitz-Linneweber
    Sequences at mitochondrial genome recombination sites are dually used as mRNAs and as rRNAs in actively translating mitoribosomes of T. gondii.
    1. Chromosomes and Gene Expression

    Dynamic spreading of chromatin-mediated gene silencing and reactivation between neighboring genes in single cells

    Sarah Lensch, Michael H Herschl ... Lacramioara Bintu
    In a synthetic system, spreading of chromatin-mediated silencing to nearby genes depends on distance and can bypass genetic insulators, while reactivation after release of gene targeting is coordinated by insulators and promoters.
    1. Neuroscience

    Control of voluntary and optogenetically perturbed locomotion by spike rate and timing of neurons of the mouse cerebellar nuclei

    Rashmi Sarnaik, Indira M Raman
    Stride-related modulated firing by neurons of the cerebellar nuclei is required for smooth execution of practiced locomotion and persists more easily with synchronous than asynchronous Purkinje-mediated inhibition.
    1. Developmental Biology

    The proteolysis of ZP proteins is essential to control cell membrane structure and integrity of developing tracheal tubes in Drosophila

    Leonard Drees, Susi Schneider ... Matthias Behr
    Genetic analyses reveal the importance of dynamic protein processing at the apical cell membrane in response to forces damaging cell membranes during tube expansion in tubular organs.
    1. Neuroscience

    Role of the postinspiratory complex in regulating swallow–breathing coordination and other laryngeal behaviors

    Alyssa Huff, Marlusa Karlen-Amarante ... Jan-Marino Ramirez
    The postinspiratory complex acts as an interface between the swallow pattern generator and the preBötzinger complex to coordinate swallow and breathing.
    1. Microbiology and Infectious Disease

    A coordinated transcriptional switching network mediates antigenic variation of human malaria parasites

    Xu Zhang, Francesca Florini ... Kirk W Deitsch
    Malaria parasites avoid destruction by their host's immune response through systematic and coordinated expression switching between members of a network of variant antigen-encoding genes, a process that is mediated by a uniquely conserved gene called var2csa.
    1. Neuroscience
    2. Physics of Living Systems

    Gigapixel imaging with a novel multi-camera array microscope

    Eric E Thomson, Mark Harfouche ... Eva A Naumann
    A new multi camera imaging platform simultaneously captures large-area, high-resolution video of unconstrained small model organisms and provides behavioral measurements that span multiple spatial scales.
    1. Neuroscience

    Effects of visual inputs on neural dynamics for coding of location and running speed in medial entorhinal cortex

    Holger Dannenberg, Hallie Lazaro ... Michael E Hasselmo
    Spatial accuracy of grid cell firing correlates with the slope of the local field potential theta frequency vs. running speed relationship and integrates velocity signals over past time.

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