1,982 results found
    1. Neuroscience

    Social dominance mediates behavioral adaptation to chronic stress in a sex-specific manner

    Stoyo Karamihalev et al.
    Social dominance has opposing effects on behavior following stress in male vs. female mice indicating an important role in sex differences in the stress response.
    1. Biochemistry and Chemical Biology
    2. Ecology

    The energy savings-oxidative cost trade-off for migratory birds during endurance flight

    Scott McWilliams et al.
    Migratory birds with fuel stores composed of more omega-6 fats saved energy during long-duration flights, but this short-term energy saving came at the long-term cost of higher oxidative damage.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Genetic mapping of etiologic brain cell types for obesity

    Pascal N Timshel et al.
    Unbiased computational integration of single-cell- and human genetics data shows that susceptibility to obesity is driven by a broad set of neuronal populations across the brain.
    1. Cancer Biology
    2. Computational and Systems Biology

    Dynamics of nevus development implicate cell cooperation in the growth arrest of transformed melanocytes

    Rolando Ruiz-Vega et al.
    Spontaneous growth arrest of transformed melanocytes (resulting in benign “moles”) does not result from cell-autonomous oncogene-induced senescence, but can be explained by collective mechanisms used in normal tissue size control.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    DDK regulates replication initiation by controlling the multiplicity of Cdc45-GINS binding to Mcm2-7

    Lorraine De Jesús-Kim et al.
    A multi-step process of helicase activation sensitizes replication initiation to the extent of replicative helicase phosphorylation.
    1. Cell Biology
    2. Physics of Living Systems

    Non-genetic inheritance restraint of cell-to-cell variation

    Harsh Vashistha et al.
    Quantitative measurement of epigenetic memory and inheritance dynamics.
    1. Developmental Biology
    2. Genetics and Genomics

    Female-biased upregulation of insulin pathway activity mediates the sex difference in Drosophila body size plasticity

    Jason W Millington et al.
    The ability to adjust body size in response to diet is greater in Drosophila females than males because of a sex difference in the nutrient-dependent regulation of the insulin pathway.
    1. Genetics and Genomics

    Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact

    Melissa A Chiasson et al.
    Human vitamin K epoxide reductase (VKOR) has a four transmembrane domain topology that supports the use of a homology model, enabling identification of active site residues and human variant impact.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Emergence and diversification of a host-parasite RNA ecosystem through Darwinian evolution

    Taro Furubayashi et al.
    In an in vitro RNA replication system, an RNA spontaneously diversifies and continuously evolves through coevolution with parasitic entities.
    1. Neuroscience

    Evolution of neuronal anatomy and circuitry in two highly divergent nematode species

    Ray L Hong et al.
    The substrate for evolutionary divergence does not lie in changes in neuronal cell number or targeting, but rather in sensory perception and synaptic partner choice within invariant, prepatterned neuronal processes.

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