1,275 results found
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    MeCP2 nuclear dynamics in live neurons results from low and high affinity chromatin interactions

    Francesco M Piccolo, Zhe Liu ... Nathaniel Heintz
    Single molecular imaging of MeCP2 at high spatial/temporal resolution identifies distinct structural domains contributing to its dynamic behaviors and chromatin interactions in live neurons.
    1. Neuroscience

    Rabphilin-3A negatively regulates neuropeptide release, through its SNAP25 interaction

    Adlin Abramian, Rein I Hoogstraaten ... Matthijs Verhage
    Live imaging at single-vesicle resolution reveals rabphilin-3A as the first identified negative regulator of neuropeptide release in mammalian neurons.
    1. Neuroscience

    Live imaging reveals the cellular events downstream of SARM1 activation

    Kwang Woo Ko, Laura Devault ... Aaron DiAntonio
    Axon degeneration occurs via an ordered sequence of events downstream of SARM1 that proceeds from ATP loss, to defects in mitochondrial movement and depolarization, followed by calcium influx, phosphatidylserine externalization, loss of membrane permeability, and ending with catastrophic axonal self-destruction.
    1. Neuroscience

    Functionally asymmetric motor neurons contribute to coordinating locomotion of Caenorhabditis elegans

    Oleg Tolstenkov, Petrus Van der Auwera ... Alexander Gottschalk
    The 'missing' class of Caenorhabditis elegans excitatory motor neurons, AS, contribute to propagation and coordination of body waves, integrating information from, and feeding back to premotor interneurons byelectrical signaling.
    1. Genetics and Genomics
    2. Neuroscience

    Opposing chemosensory functions of closely related gustatory receptors

    Ji-Eun Ahn, Hubert Amrein
    Live imaging and taste behavior analyses show that related members of the Gr28 gene subfamily are expressed in largely non-overlapping sets of neurons and mediate opposing taste behaviors.
    1. Developmental Biology

    Inter-dependent apical microtubule and actin dynamics orchestrate centrosome retention and neuronal delamination

    Ioannis Kasioulis, Raman M Das, Kate G Storey
    Microtubules are nucleated by the centrosome of the primary cilium in the apical end-foot of neuroepithelial cells and inter-dependent microtubule and actin dynamics are required here to orchestrate delamination of newborn neurons.
    1. Cell Biology
    2. Neuroscience

    KLC4 shapes axon arbors during development and mediates adult behavior

    Elizabeth M Haynes, Korri H Burnett ... Mary C Halloran
    Newly identified roles for the kinesin-1 light chain subunit KLC4 in patterning developing axon arbors, regulating microtubule dynamics and influencing behavior of larval and adult zebrafish.
    1. Developmental Biology
    2. Neuroscience

    Cross-modality synthesis of EM time series and live fluorescence imaging

    Anthony Santella, Irina Kolotuev ... Zhirong Bao
    A landmark-based cross-modality alignment method robust to variation in landmark sets is applied to annotate an EM time series of Caenorhabditis elegans embryonic development as a community resource.
    1. Developmental Biology

    Basement membranes are crucial for proper olfactory placode shape, position and boundary with the brain, and for olfactory axon development

    Pénélope Tignard, Karen Pottin ... Marie Anne Breau
    Laminin gamma1-dependent basement membranes are required for multiple aspects of olfactory system development in zebrafish, including the maintenance of placode tissue shape and the growth of the olfactory axons.

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