The cryo-EM structures of actomyosin-V, including a novel strongly bound post-rigor transition state, reveal a pronounced structural heterogeneity of myosin-V and the specific selection of the closed D-loop conformation of F-actin.

DNL343, a brain-penetrant integrated stress response inhibitor, reduces neurodegeneration in mouse models and identifies biomarker candidates for assessing treatment responses in clinical settings.

The gut microbiota of East Asians is distinct, dissociated from body mass, and self-sustains compared to White subjects from the same region, and therein may underpin a key health disparity.

ElegansBot, a two-dimensional rigid body chain model, simulates various locomotion of C. elegans, including omega and delta turns, using Newtonian equations of motion.

In multi-channel sensory systems, gain adaptation can help maintain not only coding capacity across changes in signal intensity, but also combinatorial representations of odor identity.

Transcriptomic, enzyme activity, and flux data demonstrate that metabolic scaling, the inverse correlation between body size and metabolic rate per gram of tissue, is a conserved phenomenon that occurs at multiple physiological levels and in multiple tissues.

Single cell transcriptome analysis of an embryonic collective migratory cell population provides new insights into the heterogeneity of transcriptional signatures within a neural crest cell migratory stream.

The combination of computational modeling and protein design can reveal key determinants of antibody–antigen binding and optimize small sets of antigen variants for efficient experimental localization of epitopes.

The genome of Thermovibrio ammonificans encodes ancestral pathways (e.g., hydrogen oxidation) and more recently acquired ones (e.g., nitrate reduction) and a hybrid pathway for CO₂ fixation.

The structures of secretory and dimeric IgA reveal pseudosymmetric assemblies of two antibody monomers, in which possible positions of antigen-binding fragments and accessibility to receptor-binding sites are limited.