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LncRNAs are important to stabilize postmitotic cell fate of spinal motor neurons.

Exploiting the metabolic consequences of Akt activation in prostate cancer for therapeutic interventions that circumvent Akt inhibition therapy.

DNL343, a brain-penetrant integrated stress response inhibitor, reduces neurodegeneration in mouse models and identifies biomarker candidates for assessing treatment responses in clinical settings.

Pre-existing enhancers interpret T cell signaling strength in an analogue manner to direct quantitative changes in gene expression within the context of an overall digital response.

Detailed molecular profiling investigations alongside antitumor testing and tolerability studies in animals suggest caution when considering the clinical development of inhibitors of CDK8 and CDK19, since a clear therapeutic window could not be demonstrated with two structurally distinct, potent and selective prototype drugs.

Two cancer related proteins, tyrosine phosphatase PTPRK and ubiquitin ligase ZNRF3, interact to downregulate Wnt receptors, thereby regulating Spemann organizer function during Xenopus development.

Surrogate agonist peptide ligands discovered through screening of an IAb-peptide library potentiate expansion of visceral adipose tissue resident regulatory T cells and protect mice from inflammation and improve metabolic indices.

A variable number of auxiliary subunit molecules (TARPs) accompanying AMPARs have a differential impact on channel behavior showing also striking differences between AMPAR subtypes.