3,742 results found
    1. Cancer Biology
    2. Human Biology and Medicine

    PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis

    Norihiro Yamaguchi et al.
    The gluconeogenic enzyme PCK1 and pyrimidine nucleotide biosynthetic enzyme DHODH drive hypoxic pyrimidine nucleotide biosynthesis and liver metastatic colonization in colorectal cancer, which is therapeutically exploitable by DHODH pharmacologic inhibition.
    1. Cancer Biology

    MYC and Twist1 cooperate to drive metastasis by eliciting crosstalk between cancer and innate immunity

    Renumathy Dhanasekaran et al.
    MYC and Twist1 drive metastasis by a novel non-cell-autonomous transcriptional mechanism of eliciting a cytokinome that mediates the crosstalk between cancer cells and macrophages, and its therapeutic blockade inhibits metastasis.
    1. Cancer Biology
    2. Neuroscience

    Brain tumours repurpose endogenous neuron to microglia signalling mechanisms to promote their own proliferation

    Kelda Chia et al.
    P2ry12-mediated microglial interactions stimulate the proliferation of brain tumour initiating cells.
  1. Living Science: Luck, jobs and learning

    Eve Marder
    Eve Marder believes that many of the most important events in our lives, both personal and professional, depend to some degree on luck or chance.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Precise let-7 expression levels balance organ regeneration against tumor suppression

    Linwei Wu et al.
    Mouse genetic studies reveal that let-7 performs potent tumor suppressive roles, but at the expense of regeneration and tissue homeostasis in the liver, findings with unanticipated therapeutic implications.
    1. Cell Biology
    2. Physics of Living Systems

    Microneedle manipulation of the mammalian spindle reveals specialized, short-lived reinforcement near chromosomes

    Pooja Suresh et al.
    Directly exerting force on the mammalian spindle reveals local and short-lived reinforcement in the spindle center, well-suited to preserve connections to chromosomes over seconds and yet allow remodeling over minutes.
    1. Microbiology and Infectious Disease

    Research Culture: Co-reviewing and ghostwriting by early-career researchers in the peer review of manuscripts

    Gary S McDowell et al.
    Early career researchers commonly peer review manuscripts on behalf of invited reviewers, often without receiving feedback or being named to the journal.
  2. Meta-Research: How significant are the public dimensions of faculty work in review, promotion and tenure documents?

    Juan P Alperin et al.
    An analysis of review, promotion and tenure documents from 129 US and Canadian universities suggests institutions could better fulfill their public missions by changing how they incentivize the public dimensions of faculty work.

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