751 results found
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome

    Luka Bacic et al.
    Analysis of conformational heterogeneity in cryo-EM data by a recently developed deep learning method reveals the structure and dynamics of the oncogenic chromatin remodeler ALC1 bound to a poly-ADP-ribosylated nucleosome.
    1. Microbiology and Infectious Disease

    Unexpected plasticity in the life cycle of Trypanosoma brucei

    Sarah Schuster et al.
    Parasite life cycles may be more flexible than traditionally thought, potentially allowing single-cell infections of insect vectors and transmission between hosts even at very low parasite densities.
    1. Microbiology and Infectious Disease

    Interferon receptor-deficient mice are susceptible to eschar-associated rickettsiosis

    Thomas P Burke et al.
    Type I interferon and interferon-γ signaling redundantly protects mice from the tick-borne pathogen Rickettsia parkeri in the skin, and interferon receptor-deficient mice are a tractable model for investigating rickettsiosis.
    1. Immunology and Inflammation
    2. Neuroscience

    Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave

    Lindsay A Hohsfield et al.
    In an empty microglial niche, repopulating microglia arise from subventricular zone and white matter-associated areas without contributions from the bone marrow to fill the mouse brain via a spreading wave.
    1. Epidemiology and Global Health
    2. Immunology and Inflammation

    Contrasting effects of Western vs Mediterranean diets on monocyte inflammatory gene expression and social behavior in a primate model

    Corbin SC Johnson et al.
    Modern human diet patterns alter primate behavior and monocyte gene expression leading to monocyte polarization–experimental evidence of the evolutionary mismatch hypothesis.
    1. Immunology and Inflammation

    ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation

    Miaomiao Tian et al.
    Metabolic flux analysis, biochemistry assays, and functional confirmation in mice show that the ubiquitination and degradation of ATP-citrate lyase (ACLY) mediated by CUL3-KLHL25 promotes the switch from fatty acid synthesis to fatty acid oxidation for iTreg differentiation.
    1. Cell Biology
    2. Developmental Biology

    Neuronal regulated ire-1-dependent mRNA decay controls germline differentiation in Caenorhabditis elegans

    Mor Levi-Ferber et al.
    Neuronal circuits can be disrupted by ire-1-dependent mRNA decay to affect germline tumor cell identity by regulating cross-tissue communication in Caenorhabditis elegans.
    1. Cell Biology
    2. Immunology and Inflammation

    Loss of Mir146b with aging contributes to inflammation and mitochondrial dysfunction in thioglycollate-elicited peritoneal macrophages

    Andrea Santeford et al.
    MicroRNA-146b regulates aging, activation, and mitochodrial function in thioglycollate-elicited peritoneal macrophages.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    Host-associated microbe PCR (hamPCR) enables convenient measurement of both microbial load and community composition

    Derek S Lundberg et al.
    hamPCR is a cost-effective and transformative amplicon sequencing strategy to describe microbiota composition and measure its overall abundance, applicable to all samples in which host and microbial DNA are co-extracted.
    1. Immunology and Inflammation

    HIF1α is required for NK cell metabolic adaptation during virus infection

    Francisco Victorino et al.
    During pathogen infection, natural killer cells require hypoxia-inducible factor-1α for optimal metabolism to prevent apoptosis, thereby reducing viral load and protecting against morbidity.

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