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    1. Medicine
    2. Immunology and Inflammation

    PD-L1+ Neutrophils mediate Susceptibility during Systemic Inflammatory Response in Non-Alcoholic Fatty Liver Disease

    Cleyson da Cruz Oliveira Barros, Alexandre Kanashiro ... Fernando Queiroz Cunha
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Neuroscience

    Predictive models for secondary epilepsy in patients with acute ischemic stroke within one year

    Jinxin Liu, Haoyue He ... Yongbing Deng
    Machine learning models effectively predict the risk of post-stroke epilepsy using extensive clinical data, offering new insights for improving patient management in clinical neurology.
    1. Medicine

    Dynamics of compartment-specific proteomic landscapes of hepatotoxic and cholestatic models of liver fibrosis

    Marketa Jirouskova, Karel Harant ... Martin Gregor
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Chromosomes and Gene Expression
    2. Medicine

    LncRNA Snhg3 aggravates hepatic steatosis via PPARγ signaling

    Xianghong Xie, Mingyue Gao ... Xiaojun Liu
    LncRNA-Snhg3 regulates lipid metabolism by affecting chromatin accessibility which indicates that lncRNA-mediated epigenetic modification has a crucial role in the pathology of metabolic dysfunction-associated fatty liver disease.
    1. Immunology and Inflammation

    A host enzyme reduces non-alcoholic fatty liver disease by inactivating intestinal lipopolysaccharide

    Zhiyan Wang, Nore Ojogun ... Mingfang Lu
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Medicine

    Evaluation of Gremlin-1 as a therapeutic target in metabolic dysfunction-associated steatohepatitis

    Paul Horn, Jenny Norlin ... Philip N Newsome
    Antibody-mediated neutralisation of Gremlin-1 was ineffective in treating fibrosis in metabolic dysfunction-associated steatohepatitits, likely due to low hepatic expression in a subset of myofibroblasts and redundant Gremlin-1 signalling.
    1. Biochemistry and Chemical Biology

    SIRT2-Mediated ACSS2 K271 Deacetylation Suppresses Lipogenesis Under Nutrient Stress

    Rezwana Karim, Wendi Teng ... Hening Lin
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    • Incomplete
    1. Immunology and Inflammation

    MicroRNA-26b protects against MASH development and can be efficiently targeted with lipid nanoparticles

    Linsey JF Peters, Leonida Rakateli ... Emiel PC van der Vorst
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Developmental Biology
    2. Medicine

    SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic dysfunction

    Stephen E Flaherty III, Olivier Bezy ... Zhidan Wu
    Investigation of mouse models from forward mutagenetic screen reveals that the gene Spag7 is essential for embryonic development and energy homeostasis later in life.
    1. Medicine

    Liver microRNA transcriptome reveals miR-182 as link between type 2 diabetes and fatty liver disease in obesity

    Christin Krause, Jan H Britsemmer ... Henriette Kirchner
    The liver microRNA transcriptome of humans with type 2 diabetes and obesity is analyzed for the first time and compared with diet-induced obesity in mice.
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