Multiple alleles of Txnip, which can interact with several different proteins, including Hsp90AB1, were tested for their ability to prolong the survival of cone photoreceptors in diseases leading to blindness.
Natalia E Ketaren, Fred D Mast ... John D Aitchison
High-affinity nanobodies targeting the SARS-CoV-2 spike protein demonstrate sustained effectiveness against current and emerging variants, offering a promising avenue for treatment.
Christian Galicia, Giambattista Guaitoli ... Wim Versées
Conformation-specific nanobodies enable to capture and solve the first GTP-bound active structure of a bacterial homolog of the Parkinson-associated LRRK2 protein, providing insights into the activation mechanism of these proteins.
Pratik Rajan Gupte, Gregory F Albery ... Franz J Weissing
The introduction of infectious pathogens to a simulated animal population leads to rapid evolutionary transitions in how individuals move in a social context, with distinct movement morphs evolved that make trade-offs between sociality and infection risk.
