151 results found
    1. Neuroscience

    Voltage-gated Na+ currents in human dorsal root ganglion neurons

    Xiulin Zhang et al.
    Human sensory neurons may not only bridge a critical gap between drug discovery and clinical trials, but force a re-evaluation of basic assumptions about the mechanisms controlling primary afferent excitability.
    1. Neuroscience

    Medial entorhinal cortex activates in a traveling wave in the rat

    J Jesús Hernández-Pérez et al.
    The existence of traveling waves in the medial entorhinal cortex, like those observed in the hippocampus, supports the hypothesis that traveling waves coordinate the activity of anatomically distributed circuits.
    1. Cell Biology
    2. Neuroscience

    Transverse tubule remodeling enhances Orai1-dependent Ca2+ entry in skeletal muscle

    Antonio Michelucci et al.
    Structural and functional analyses show that transverse tubule association with stacks of sarcoplasmic reticulum enhances Orai1-dependent Ca2+ entry to replenish Ca2+ stores, maintain Ca2+ release, and maximize force during exercise.
    1. Neuroscience

    Kv1.1 contributes to a rapid homeostatic plasticity of intrinsic excitability in CA1 pyramidal neurons in vivo

    Peter James Morgan et al.
    Short, theta-bursts of action potential firing decrease the global excitability of CA1 pyramidal neurons, providing an internal mechanism which could regulate their allocation to memory engrams.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    'Palaeoshellomics’ reveals the use of freshwater mother-of-pearl in prehistory

    Jorune Sakalauskaite et al.
    Ancient proteomes from tiny shell ornaments were successfully characterised for the first time, showing the unexpected use of mother-of-pearl from local riverine molluscs in both coastal and inland prehistoric sites.
    1. Neuroscience

    Neural circuitry of a polycystin-mediated hydrodynamic startle response for predator avoidance

    Luis A Bezares-Calderón et al.
    The Platynereis startle circuit links polycystin-dependent hydrodynamic sensors to muscle and ciliary effector cells.
    1. Neuroscience

    Functional properties of stellate cells in medial entorhinal cortex layer II

    David C Rowland et al.
    Stellate cells in the medial entorhinal cortex are functionally heterogeneous but a substantial fraction are grid cells.
    1. Neuroscience

    Attenuation of dopamine-modulated prefrontal value signals underlies probabilistic reward learning deficits in old age

    Lieke de Boer et al.
    Attenuated anticipatory activity in ventromedial prefrontal cortex is modulated by dopamine D1 receptor density in nucleus accumbens, and accounts for impaired probabilistic reward learning in older adults.
    1. Neuroscience

    Feedforward motor information enhances somatosensory responses and sharpens angular tuning of rat S1 barrel cortex neurons

    Mohamed Khateb et al.
    Primary motor cortex afferents supra-linearly amplify the responses and sharpen angular tuning of neurons in the S1 barrel cortex.
    1. Neuroscience

    Inhibitory control of correlated intrinsic variability in cortical networks

    Carsen Stringer et al.
    A new cortical network model fit directly to multi-neuron recordings reveals that local inhibitory feedback can control neural dynamics, modulate brain state and enhance sensory processing.

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