2,494 results found
  1. Episode 44: January 2018

    In this episode, we hear about self-esteem, a new genus of extinct horse, the future of biological engineering, mosquito trackers, and sperm competition in salmon.
    1. Microbiology and Infectious Disease

    Mechanistic Microbiome Studies: A Special Issue

    Curated by Wendy S Garrett et al.
    eLife is pleased to present a Special Issue to highlight recent advances in the mechanistic understanding of microbiome function.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease
    Tropical disease

    Tropical Disease: A Collection of Articles

    Curated by Prabhat Jha et al.
    eLife has published papers on many tropical diseases, including malaria, Ebola, leishmaniases, Dengue and African sleeping sickness.
  2. Looking at lipids: an interview with Jessica Hughes

    Jessica Hughes is a lecturer in medical sciences at the University of Wollongong, Australia. Her research focuses on the role of lipids in health and disease. She currently lives with her husband Lucas and their three dogs in Wollongong, where she enjoys walking the dogs on the local off-leash beach every morning.
    1. Neuroscience

    Acute intermittent hypoxia enhances corticospinal synaptic plasticity in humans

    Lasse Christiansen et al.
    Acute intermittent hypoxia is a noninvasive approach that enhances corticospinal function in humans, likely through alterations in corticospinal-motoneuronal synaptic transmission.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals

    Shogo Sawaguchi et al.
    The transfer of O-GlcNAc by EOGT to specific EGF repeats of NOTCH1 promotes DLL4 binding, Notch signaling, and retinal vascular development.
    1. Stem Cells and Regenerative Medicine

    Neural stem cells induce the formation of their physical niche during organogenesis

    Ali Seleit et al.
    A physical niche for neural stem cells is generated by the induction of the immediate skin epithelium, a process triggered by the arrival of neural precursors during sensory organ formation in medaka.
    1. Neuroscience

    Lognormal firing rate distribution reveals prominent fluctuation–driven regime in spinal motor networks

    Peter C Petersen, Rune W Berg
    Neuronal participation in generation of motor patterns in the spinal circuits is lognormal, which is an indication of a rich diversity of activity within the mean-driven as well as the fluctuation-driven regimes.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    The major β-catenin/E-cadherin junctional binding site is a primary molecular mechano-transductor of differentiation in vivo

    Jens-Christian Röper et al.
    The primary molecular mechanosensor involved in a physiological process of mechanically induced cell fate differentiation is revealed here for the first time in vivo, highly sensitive and potentially shared by all metazoan epithelia.
    1. Developmental Biology
    2. Neuroscience

    Pioneer neurog1 expressing cells ingress into the otic epithelium and instruct neuronal specification

    Esteban Hoijman et al.
    Quantitative 4D image analysis identifies a group of cells which enter into the otic primordium during morphogenesis and instructs neuronal specification.

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