3,241 results found
    1. Cell Biology
    2. Computational and Systems Biology

    Decoupling global biases and local interactions between cell biological variables

    Assaf Zaritsky et al.
    DeBias is a generic method to decompose and quantify the confounding, global factors and direct interactions of pairwise interacting variables.
    1. Cell Biology
    2. Neuroscience

    The SNAP-25 linker supports fusion intermediates by local lipid interactions

    Ahmed Shaaban et al.
    The SNAP-25 linker acts as a functional component of SNARE complexes, initially facilitating SNARE interactions and later promoting fusion triggering and pore evolution by local membrane contacts.
    1. Developmental Biology

    Local cell interactions and self-amplifying individual cell ingression drive amniote gastrulation

    Octavian Voiculescu et al.
    A combination of two local cell interactions, intercalation and ingression amplified by a community-effect, is sufficient to explain the global movements of amniote gastrulation.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions

    Benjamin P Bouchet et al.
    Interactions between talin1 and a cortical scaffolding protein KANK1 control microtubule stabilization in the vicinity of focal adhesions.
    1. Neuroscience

    Vocal development in a Waddington landscape

    Yayoi Teramoto et al.
    An integrated landscape framework shows how the coordinated changes in vocal apparatus, muscles, nervous system, and social interaction together influence the trajectory of vocal development.
    1. Neuroscience

    Female mice ultrasonically interact with males during courtship displays

    Joshua P Neunuebel et al.
    A microphone array enables the vocal contribution of each socially interacting individual to be quantified, and reveals that vocalizations are exchanged between the sexes during mouse courtship.
    1. Neuroscience

    Dendritic NMDA receptors in parvalbumin neurons enable strong and stable neuronal assemblies

    Jonathan H Cornford et al.
    NMDA receptors on PV+ interneurons mediate supralinear integration at feedback synapses from local pyramidal neurons, enabling competing networks to ‘lock’ onto salient inputs.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Single-molecule observation of DNA compaction by meiotic protein SYCP3

    Johanna L Syrjänen et al.
    Building on previous work (Syrjänen, Pellegrini, & Davies, 2014), it is shown that SYCP3 contributes to the architecture of meiotic chromosomes through local bridging interactions that result in large-scale compaction of the chromosome axis.
    1. Neuroscience

    Local synaptic inputs support opposing, network-specific odor representations in a widely projecting modulatory neuron

    Xiaonan Zhang et al.
    The activity of serotonergic neurons spanning multiple olfactory areas is regulated by both local synaptic interactions and dendrite wide computations.

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