Cortical astrocytes play key roles in NREM sleep by regulating sleep depth and duration through separate GPCR pathways, and differentially control neuronal slow-wave activity in local and remote cortical circuits.
Theory explains how transport of gene expression vortices by cell advection may cause intermingled defective and normal segments along the body axis during resynchronization experiments in the zebrafish segmentation clock.
β-adrenergic receptors at the Golgi apparatus activate a local signaling pathway, not accessed by cell surface receptors, to drive cardiac hypertrophy and could represent a target for heart failure therapy.
Genetic studies in mice reveal the molecular and embryological mechanisms of vocal fold development and function, thereby informing our understanding of vocal communication and congenital voice defects.
Genetic analyses in mice reveal a communication system between the knee joint and the developing bones that could be explored in studies addressing evolutionary changes in body proportions and in future therapies for growth disorders.
The powerful computational operation of sequence recognition on behavioral timescales of approximately 1 s may emerge from synaptic activity-triggered build-up of biochemical waves in short 20 micron zones on dendrites.