1,127 results found
    1. Microbiology and Infectious Disease

    Differential requirements for cyclase-associated protein (CAP) in actin-dependent processes of Toxoplasma gondii

    Alex Hunt, Matthew Robert Geoffrey Russell ... Moritz Treeck
    Partially overlapping functions of a limited subset of actin binding proteins allow the parasite Toxoplasma gondii to achieve actin regulation required for complex cellular processes.
    1. Evolutionary Biology

    Palatal morphology predicts the paleobiology of early salamanders

    Jia Jia, Guangzhao Li, Ke-Qin Gao
    Salamanders originate as metamorphosed with a biphasic lifestyle as shown by the palate shape and several non-shape features associated with the vomerine teeth, with diverse ecological types displayed in living species achieved in the Early Cretaceous.
    1. Cell Biology

    The molecular mechanism of load adaptation by branched actin networks

    Tai-De Li, Peter Bieling ... Daniel A Fletcher
    An actin-based Brownian Ratchet enables branched actin networks to generate pushing forces, while a capping protein-based Brownian Ratchet provides force feedback that enables these networks to adapt their architecture in response to changing loads.
    1. Evolutionary Biology

    A new Heterodontosaurus specimen elucidates the unique ventilatory macroevolution of ornithischian dinosaurs

    Viktor J Radermacher, Vincent Fernandez ... Jonah N Choiniere
    A new specimen of Heterodontosaurus elucidates how ornithischian dinosaurs evolved a body plan substantially different from that of other dinosaurs and what these differences meant for their breathing.
    1. Biochemistry and Chemical Biology
    2. Physics of Living Systems

    Mechanically transduced immunosorbent assay to measure protein-protein interactions

    Christopher J Petell, Kathyrn Randene ... Joshua P Steimel
    METRIS is a method that reports a mechanical readout of protein-protein interactions and due to its unique properties, it will allow many protein-protein interactions to be quantitatively measured easily that are currently laborious to measure with conventional methods.
    1. Evolutionary Biology

    Rampant tooth loss across 200 million years of frog evolution

    Daniel J Paluh, Karina Riddell ... David C Blackburn
    Teeth are maintained in two amphibian groups (caecilians and salamanders) but were lost in frogs over 20 times independently, a higher incidence of edentulism than any other major vertebrate group.
    1. Developmental Biology
    2. Evolutionary Biology

    Selection for increased tibia length in mice alters skull shape through parallel changes in developmental mechanisms

    Colton M Unger, Jay Devine ... Campbell Rolian
    Artificial selection for increased tibia length in mice made their skulls longer, narrower, and flatter, suggesting that even distant skeletal regions can evolve as correlated responses to selection acting locally.
    1. Computational and Systems Biology
    2. Neuroscience

    Probable nature of higher-dimensional symmetries underlying mammalian grid-cell activity patterns

    Alexander Mathis, Martin B Stemmler, Andreas VM Herz
    Mathematical analysis confirms that hexagonal patterns of neuronal activity are the most efficient means for the brain to represent 2D space, and predicts that activity patterns resembling densely packed lattices are optimal for representing 3D space.
    1. Genetics and Genomics
    2. Neuroscience

    Machine learning sequence prioritization for cell type-specific enhancer design

    Alyssa J Lawler, Easwaran Ramamurthy ... Andreas R Pfenning
    A new cross-species machine learning-based strategy is applied to find enhancers that specifically label parvalbumin neurons in the mouse and macaque.

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