923 results found
    1. Neuroscience

    Evolution of neuronal anatomy and circuitry in two highly divergent nematode species

    Ray L Hong et al.
    The substrate for evolutionary divergence does not lie in changes in neuronal cell number or targeting, but rather in sensory perception and synaptic partner choice within invariant, prepatterned neuronal processes.
    1. Neuroscience

    RIM is essential for stimulated but not spontaneous somatodendritic dopamine release in the midbrain

    Brooks G Robinson et al.
    Midbrain dopamine neurons use sophisticated secretory machinery to establish specialized sites for action potential-evoked release of dopamine from their cell bodies and dendrites.
    1. Neuroscience

    CELF RNA binding proteins promote axon regeneration in C. elegans and mammals through alternative splicing of Syntaxins

    Lizhen Chen et al.
    Genetics and genomics approaches reveal a conserved post-transcriptional regulatory mechanism that promotes adult axon regeneration from worm to mammals.
    1. Developmental Biology
    2. Physics of Living Systems

    Rolling controls sperm navigation in response to the dynamic rheological properties of the environment

    Meisam Zaferani et al.
    Rheological properties of the environment regulate sperm swimming and navigational behavior through suppression or reactivation of sperm rolling around its longitudinal axis.
    1. Structural Biology and Molecular Biophysics

    Cadherin clusters stabilized by a combination of specific and nonspecific cis-interactions

    Connor J Thompson et al.
    A combined experimental and computational approach was developed to understand lateral interactions between membrane-bound proteins and used to quantify the contributions of specific and non-specific interactions to cadherin cis-binding kinetics.
    1. Developmental Biology
    2. Physics of Living Systems

    Nuclear crowding and nonlinear diffusion during interkinetic nuclear migration in the zebrafish retina

    Afnan Azizi et al.
    The evolving spatial distribution of nuclei between apical and basal surfaces of the developing retinal neuroepithelium is quantitatively described by a nonlinear diffusion equation accounting for crowding within the tissue.
    1. Neuroscience

    Dynamic control of hippocampal spatial coding resolution by local visual cues

    Romain Bourboulou et al.
    Hippocampal spatial coding resolution can quickly adapt to local visual cues within a given environment.
    1. Stem Cells and Regenerative Medicine
    2. Neuroscience

    A functional genomics screen in planarians reveals regulators of whole-brain regeneration

    Rachel H Roberts-Galbraith et al.
    A gene expression-guided functional screen identifies factors and cell types that regulate diverse aspects of neural regeneration in planarians.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    High-speed, three-dimensional imaging reveals chemotactic behaviour specific to human-infective Leishmania parasites

    Rachel C Findlay et al.
    High-speed holographic microscopy shows that Leishmania parasites modify their swimming behaviour to target human macrophages.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Onset of taste bud cell renewal starts at birth and coincides with a shift in SHH function

    Erin J Golden et al.
    Taste cell renewal begins at birth and is promoted by sonic hedgehog that alters the expression of regulators of cell migration and adhesion that may allow entry of new cells into buds.

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