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The conformation of an isoleucine gate located along the TM6 segment on the intracellular side below the selectivity filter is a critical component leading to a non-conductive state in the C-type inactivation process of K⁺ channels.

In vivo analysis of endogenously tagged Ca²⁺ channel subunits reveals unexpected differences in subunit composition and synapse-specific relationships between channel abundance and synaptic strength.

Notch signaling controls the collective migration of parapineal cells through its capacity to restrict FGF pathway activation to a few leading cells.

Mutations that affect a metabolic network generically exhibit epistasis, which propagates to higher level phenotypes, such as fitness, carrying some information about the network’s topology.

Intentionally preventing the retrieval of an unwanted memory hinders future attempts to reactivate the memory’s neural representation and causes a reduction in the vividness with which it can be recalled.

Direct and indirect pathway neurons in posterior dorsomedial striatum were found to play distinct roles, with the former necessary for encoding and the latter for updating goal-directed learning.

Mitochondrial energy metabolism is post-transcriptionally regulated through an interplay between long and short non-coding RNAs.

Secondary thalamic nuclei may provide stronger, longer-lasting input to superficial layers of primary sensory cortex than other cortical areas can.

Whole-genome in silico screening for stop codon contexts that produce elevated translational readthrough and peroxisome targeting reveals that in mammals, the amount of lactate dehydrogenase in the peroxisome is controlled by translational readthrough.

High-throughput RNA-RNA interaction analysis uncovers many novel sRNA-target interactions at various growth stages in Escherichia coli.