544 results found
    1. Computational and Systems Biology

    Stochastic logistic models reproduce experimental time series of microbial communities

    Lana Descheemaeker, Sophie de Buyl
    Properties of various microbial communities time series, such as the noise color and neutrality, are captured by stochastic generalized Lotka-Volterra equations, even in the absence of interactions.
    1. Epidemiology and Global Health

    Determinants of MDA impact and designing MDAs towards malaria elimination

    Bo Gao et al.
    The impact of mass intervention campaigns is determined by the interaction between implementation logistics, patterns of human mobility and how transmission risk is distributed over space.
    1. Epidemiology and Global Health
    2. Immunology and Inflammation

    A single, continuous metric to define tiered serum neutralization potency against HIV

    Peter Hraber et al.
    To quantify serum or antibody activity against HIV-1, logistic regression of single-dilution neutralization outcomes can efficiently summarize neutralization potency and indicate which samples may lack sufficient statistical support, for high-throughput screening in large-scale vaccine trials.
    1. Developmental Biology

    Cellular resolution models for even skipped regulation in the entire Drosophila embryo

    Garth R Ilsley et al.
    A statistical model is able to predict patterns of gene expression output in Drosophila embryos using only the cellular concentrations of transcription factors as input.
    1. Epidemiology and Global Health

    Time-to-event modeling of hypertension reveals the nonexistence of true controls

    Daniel Shriner et al.
    Despite health disparities among groups, the lifetime risk of hypertension approaches 100% for African Americans, European Americans, and Mexican Americans.
    1. Neuroscience

    Associability-modulated loss learning is increased in posttraumatic stress disorder

    Vanessa M Brown et al.
    Veterans with PTSD show increased attention to a history of unexpected outcomes during loss learning, both as measured by computational model-derived behavioral parameters and in increased neural signaling in amygdala and insula.
    1. Computational and Systems Biology

    Hidden long-range memories of growth and cycle speed correlate cell cycles in lineage trees

    Erika E Kuchen et al.
    The combination of statistical inference and perturbation experiments reveals that trans-generational inheritance of cell size and cell-cycle speed, coupled through a minimum-size checkpoint, shapes paradoxical cell-cycle correlations in lineage trees.
  1. Scientist and Parent: Are we there yet?

    Nicole Swann
    Traveling to conferences with children presents a number of logistical and financial challenges.
    1. Computational and Systems Biology

    Meta-Research: Centralized scientific communities are less likely to generate replicable results

    Valentin Danchev et al.
    Analysis of data on drug-gene interactions suggests that decentralized collaboration will increase the robustness of scientific findings in biomedical research.
  2. Research Culture: Career choices of underrepresented and female postdocs in the biomedical sciences

    W Marcus Lambert et al.
    Mentorship, financial security and a positive sense of self-worth increase the likelihood that underrepresented minority and female postdocs will pursue a career in academia.

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