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The localization of Rad53 cell cycle checkpoint kinase to many gene promoters and the dynamic changes in response to replication stress suggests that the kinase may coordinate genome stability and gene expression.

An experimental animal model provides further insights into the host and viral mechanisms underlying airborne transmission of SARS-CoV-2.

A new type of biologically constrained spiking neural network model applied to the dorsal raphe nucleus shows that the output of the serotonin system reflects not just its raw input, but mainly how quickly its input changes over time.

Tight nuclear tethering of the cGAS DNA sensor maintains it in its resting state and prevents activation by self-DNA.

In glioblastoma stem cells, oncogenes on extrachromosomal DNA do not cluster at distances in keeping with coordinated transcription, with amplified gene expression driven by copy number rather increased transcriptional efficiency.

Novel Cas9 fusion with DNA polymerase delta subunit 3 (POLD3), identified via high-throughput screening of more than 450 DNA repair proteins, enhances editing by speeding up the initiation of DNA repair.

Genetic and cell biological analyses reveal a new role of Drp1 in postsynaptic endocytosis during brain development beyond mitochondrial division GTPase.

Type IV collagen plays a dual role in both structurally fastening tissues and signaling through the discoidin domain receptor 2 to synchronize an integrin adhesion that stabilizes tissue linkage.

A large interneuron in the Drosophila mushroom body has compartmentalized activity, which causes localized inhibition and predicts that Kenyon cells inhibit themselves more than they inhibit other individual Kenyon cells.

The cell-surface protein Stranded at second is a targeting ligand for extracellular vesicles that can deliver dArc1 capsids containing dArc1 mRNA to distant cells in vivo.