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Page 2 of 492
    1. Neuroscience

    Immediate perception of a reward is distinct from the reward’s long-term salience

    John P McGinnis, Huoqing Jiang ... Kausik Si
    The experiences that are most rewarding at the time are not necessarily those that are remembered long-term.
    1. Computational and Systems Biology
    2. Developmental Biology

    High-throughput mathematical analysis identifies Turing networks for patterning with equally diffusing signals

    Luciano Marcon, Xavier Diego ... Patrick Müller
    Realistic reaction-diffusion signaling networks that include cell-autonomous factors can robustly form self-organizing spatial patterns for any combination of diffusion coefficients without requiring differential diffusivity.
    1. Neuroscience

    Long-term stability of cortical ensembles

    Jesús Pérez-Ortega, Tzitzitlini Alejandre-García, Rafael Yuste
    Spontaneous and visually evoked neuronal ensembles in mouse visual cortex can last for weeks, potentially supporting the long-lasting representation of perceptions and memories.
    1. Neuroscience

    Reward signal in a recurrent circuit drives appetitive long-term memory formation

    Toshiharu Ichinose, Yoshinori Aso ... Hiromu Tanimoto
    A recurrent reward circuit in Drosophila, comprised of specific dopamine neurons and a single class of mushroom body output neurons, transforms a nascent memory trace into a stable long-term memory.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Atypical calcium regulation of the PKD2-L1 polycystin ion channel

    Paul G DeCaen, Xiaowen Liu ... David E Clapham
    Outward calcium ion currents desensitize the human PKD2-L1 ion channel via a mechanism that is independent of cytosolic motifs.
    1. Microbiology and Infectious Disease

    Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and rectal reservoirs

    Eva Malatinkova, Ward De Spiegelaere ... Linos Vandekerckhove
    An early start to long-term antiretroviral therapy limits the size of the HIV-1 reservoir more effectively than treatment that starts later.
    1. Developmental Biology
    2. Neuroscience

    Retinoic acid signaling mediates peripheral cone photoreceptor survival in a mouse model of retina degeneration

    Ryoji Amamoto, Grace K Wallick, Constance L Cepko
    Retinoic acid signaling from Muller glia is necessary for cone photoreceptor survival in the peripheral retina and is sufficient to promote cone survival in the central retina during retinal degeneration.
    1. Neuroscience

    Recurrent network model for learning goal-directed sequences through reverse replay

    Tatsuya Haga, Tomoki Fukai
    The combination of short-term and long-term plasticity enables hippocampus to learn goal-directed paths through replay in a reversed order.
    1. Developmental Biology

    Kinetics of blood cell differentiation during hematopoiesis revealed by quantitative long-term live imaging

    Kevin Yueh Lin Ho, Rosalyn Leigh Carr ... Guy Tanentzapf
    A long-term multi-organ co-culture system coupled with quantitative imaging to visualize blood cell cycle progression, analyze polarized blood cell mitosis, and track blood cell differentiation kinetics during Drosophila hematopoiesis in homeostatic condition and following infection.
    1. Neuroscience

    Optogenetic induction of appetitive and aversive taste memories in Drosophila

    Meghan Jelen, Pierre-Yves Musso ... Michael D Gordon
    Closed-loop pairing of taste stimuli with optogenetic activation of neurons encoding either reward or punishment reveals that flies can form both appetitive and aversive taste memories that impact their future behavioral responses to tastes.