210 results found
  1. November 2015

    Episode 25: November 2015

    In this episode we hear about deep-sea bacteria, cigarette smoke and lung disease, antibiotic resistance, unconscious perception, and the benefits of sleep.
    1. Neuroscience

    Salient experiences are represented by unique transcriptional signatures in the mouse brain

    Diptendu Mukherjee et al.
    Inducible transcription in the brain encodes detailed aspects of recent experience.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Transition between fermentation and respiration determines history-dependent behavior in fluctuating carbon sources

    Bram Cerulus et al.
    Live-cell microscopy and genome-wide screens reveal how slow transitions in metabolism can underlie metabolic memory, providing a model for organisms demonstrating similar history-dependent behaviour and routes to improve industrial microbes.
    1. Neuroscience

    Real-time classification of experience-related ensemble spiking patterns for closed-loop applications

    Davide Ciliberti et al.
    A brain–computer interface for real-time identification of transient neural activity patterns enables causal inference of the role of these patterns in cognition through closed-loop manipulation.
    1. Computational and Systems Biology
    2. Developmental Biology

    A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment

    Kenneth KH Ng et al.
    The timing and outcome of mammalian cell lineage decisions can be controlled by slow, stochastic events on individual regulatory gene loci.
    1. Neuroscience

    Uncovering temporal structure in hippocampal output patterns

    Kourosh Maboudi et al.
    Machine learning models of coordinated hippocampal ensemble activity during sharp wave ripple activity encode structure that mirrors the place cell map expressed during exploration, and enable a new paradigm for analyzing and understanding this offline activity.
    1. Cell Biology

    Cortical bone maturation in mice requires SOCS3 suppression of gp130/STAT3 signalling in osteocytes

    Emma C Walker et al.
    Targeted SOCS3 null mice reveal that maturation of cortical bone comprises both pore closure and accumulation of high density bone, requiring local suppression of gp130-STAT3 in osteocytes and subsequent osteoclastogenesis.
    1. Neuroscience

    The Ionotropic Receptors IR21a and IR25a mediate cool sensing in Drosophila

    Lina Ni et al.
    Two members of a widely studied family of chemoreceptors, the "orphan" chemoreceptor IR21a and its putative co-receptor IR25a, act together to mediate cool sensation in fruit fly larvae.
    1. Neuroscience

    Neural evidence accumulation persists after choice to inform metacognitive judgments

    Peter R Murphy et al.
    Error detection is contingent on the continuation of evidence accumulation after choice commitment, and the speed and accuracy of this process are modulated by high-level signals from medial frontal cortex.
    1. Neuroscience

    Frontal beta-theta network during REM sleep

    Sujith Vijayan et al.
    Two regions of the frontal lobe – the anterior cingulate cortex and, unexpectedly, the dorsolateral prefrontal cortex – show coordinated rhythmic activity during REM sleep.

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