694 results found
    1. Microbiology and Infectious Disease

    Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and rectal reservoirs

    Eva Malatinkova, Ward De Spiegelaere ... Linos Vandekerckhove
    An early start to long-term antiretroviral therapy limits the size of the HIV-1 reservoir more effectively than treatment that starts later.
  1. Research: Decoupling of the minority PhD talent pool and assistant professor hiring in medical school basic science departments in the US

    Kenneth D Gibbs Jr, Jacob Basson ... David A Broniatowski
    A systems-level analysis of the biomedical workforce in the US shows that current strategies to enhance faculty diversity are unlikely to have a significant impact, and that there is a need to increase the number of PhDs from underrepresented minority backgrounds who move on to postdoctoral positions.
    1. Neuroscience

    Independent and interacting value systems for reward and information in the human brain

    Irene Cogliati Dezza, Axel Cleeremans, William H Alexander
    Reward and information are independently optimized in the human prefrontal cortex, while their signals combine in subcortical regions.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Human MAIT cells respond to and suppress HIV-1

    Chansavath Phetsouphanh, Prabhjeet Phalora ... Paul Klenerman
    In depth phenotyping from tissues and in vitro activation studies reveal antiviral function of MAIT cells- with particular emphasis on HIV infection.
    1. Epidemiology and Global Health
    2. Immunology and Inflammation

    A single, continuous metric to define tiered serum neutralization potency against HIV

    Peter Hraber, Bette Korber ... Mario Roederer
    To quantify serum or antibody activity against HIV-1, logistic regression of single-dilution neutralization outcomes can efficiently summarize neutralization potency and indicate which samples may lack sufficient statistical support, for high-throughput screening in large-scale vaccine trials.
    1. Computational and Systems Biology
    2. Neuroscience

    Neuroimaging and behavioral evidence that violent video games exert no negative effect on human empathy for pain and emotional reactivity to violence

    Lukas Leopold Lengersdorff, Isabella C Wagner ... Claus Lamm
    After playing violent video games for 7 hr over the course of 2 weeks, human male participants show neither signs of decreased empathy for the pain of another person nor of decreased responsivity to violent images.
    1. Neuroscience

    The cortical connectivity of the periaqueductal gray and the conditioned response to the threat of breathlessness

    Olivia K Faull, Kyle TS Pattinson
    Building on previous work (Faull et al, 2016), it shown that the different connectivity profiles of the individual columns of the human periaqueductal gray support their proposed roles in human threat behaviours, such as freezing or fight/flight.
  2. Meta-Research: Gender variations in citation distributions in medicine are very small and due to self-citation and journal prestige

    Jens Peter Andersen, Jesper Wiborg Schneider ... Mathias Wullum Nielsen
    In studies of gender disparities in academia, increased focus is required on within-group variability and between-group overlap of distributions when interpreting and reporting results.
    1. Structural Biology and Molecular Biophysics

    Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2

    Dari Kimanius, Björn O Forsberg ... Erik Lindahl
    Using GPUs for the costly computations in cryo-EM enables structure determination in mere days on a single workstation.
    1. Neuroscience

    Consistent patterns of distractor effects during decision making

    Bolton KH Chau, Chun-Kit Law ... Matthew FS Rushworth
    The value of any choice is not static but dynamically changes as a function of the context of the alternatives even if they are seemingly irrelevant.

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