1,372 results found
    1. Neuroscience
    2. Computational and Systems Biology

    Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning

    Rui Ponte Costa et al.
    Combined pre- and postsynaptically expressed long-term plasticity of neuronal connections improves sensory discrimination, and enables rapid relearning of previously encountered information.
    1. Neuroscience

    The fate of hippocampal synapses depends on the sequence of plasticity-inducing events

    J Simon Wiegert et al.
    Non-invasive optogenetic induction of synaptic plasticity revealed that long-term potentiation and long-term depression alter the chances of a synapse to survive the next seven days.
    1. Neuroscience

    Long term functional plasticity of sensory inputs mediated by olfactory learning

    Nixon M Abraham et al.
    Associative learning, but not passive odorant exposure, induces a novel long lasting functional plasticity in the periphery of mouse olfactory system, making previously encountered odors easier to detect in the future.
    1. Neuroscience

    The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory

    Leanne J M Schmitz et al.
    Shisa7 is a bona-fide AMPAR modulatory protein affecting channel kinetics of hippocampal AMPARs, and is necessary for synaptic plasticity and memory recall.
    1. Neuroscience

    Kv1.1 contributes to a rapid homeostatic plasticity of intrinsic excitability in CA1 pyramidal neurons in vivo

    Peter James Morgan et al.
    Short, theta-bursts of action potential firing decrease the global excitability of CA1 pyramidal neurons, providing an internal mechanism which could regulate their allocation to memory engrams.
    1. Neuroscience

    Presynaptic PTPσ regulates postsynaptic NMDA receptor function through direct adhesion-independent mechanisms

    Kyungdeok Kim et al.
    Presynaptic adhesion molecule PTPσ in the hippocampus regulates postsynaptic NMDA receptor function and behavioral novelty recognition through mechanisms independent of their trans-synaptic binding partners.
    1. Neuroscience

    Self-organized reactivation maintains and reinforces memories despite synaptic turnover

    Michael Jan Fauth, Mark CW van Rossum
    Despite ongoing rewiring and continuous turnover of synapses, a computational model shows that memories can maintain and even strengthen their connectivity by self-reactivating during periods without sensory input.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Satb2 determines miRNA expression and long-term memory in the adult central nervous system

    Clemens Jaitner et al.
    The genome-organizer Satb2 has a key role in memory formation by modulating availability of miRNAs that control the function of synapses.
    1. Neuroscience

    Structural plasticity of dendritic secretory compartments during LTP-induced synaptogenesis

    Yelena D Kulik et al.
    The secretory and recycling components of neuronal dendrites, smooth endoplasmic reticulum and endosomes, were discovered to support synaptogenesis underlying a cellular mechanism of learning and memory in the developing brain.

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