921 results found
    1. Epidemiology and Global Health

    Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up

    Xia Li et al.
    Biological ages have the potential to provide aging-related information beyond chronological age and can be predictive of mortality independently of both chronological age and different types of biological ages.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection

    Anastasia A Minervina et al.
    Longitudinal tracking of individual T-cell clones reveals the expansion of pre-existing T-cell memory in response to SARS-CoV-2 infection.
    1. Neuroscience

    Hippocampal activation is associated with longitudinal amyloid accumulation and cognitive decline

    Stephanie L Leal et al.
    Cognitively normal older adults show a positive relationship between neural activity during memory encoding and brain β-amyloid deposition rate over the subsequent 3-4 years, supporting preclinical data that associates neural activity with β-amyloid deposition.
    1. Neuroscience

    A longitudinal study of Caenorhabditis elegans larvae reveals a novel locomotion switch, regulated by Gαs signaling

    Stanislav Nagy et al.
    C. elegans exhibits two distinct behavioural macro-states, active and quiet wakefulness, and protein kinase A regulates switching between these two states.
    1. Neuroscience

    Dissociable roles of the inferior longitudinal fasciculus and fornix in face and place perception

    Carl J Hodgetts et al.
    Structure-function associations in medial temporal lobe reflect specialised, behaviourally-relevant neurocognitive circuits for the perception of faces and places.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Longitudinal imaging of Caenorhabditis elegans in a microfabricated device reveals variation in behavioral decline during aging

    Matthew A Churgin et al.
    The WorMotel, a novel microfabricated device for automated longitudinal imaging of aging in large numbers of Caenorhabditis elegans, reveals that long and short lived strains vary in their behavioral decline during aging in a similar way to the long and short lived individuals in a wild type population.
    1. Physics of Living Systems

    Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy

    Ambjorn Brynnel et al.
    Genetically altering the size of the molecular spring element in the giant protein titin established that titin determines the stiffness of skeletal muscle and the number of sarcomeres in series.
    1. Neuroscience

    Longitudinal stability of medial temporal lobe connectivity is associated with tau-related memory decline

    Quanjing Chen et al.
    Phosphorylated tau was related to a loss of structural stability in medial temporal lobe connectivity, and this loss of stability moderated the relationship between phosphorylated tau accumulation and memory decline.
    1. Microbiology and Infectious Disease

    Longitudinal imaging of HIV-1 spread in humanized mice with parallel 3D immunofluorescence and electron tomography

    Collin Kieffer et al.
    Combined tissue clearing, 3D-immunofluorescence, and electron tomography spatially revealed the dynamics of early HIV-1 spread within lymphoid tissues of humanized mice at the resolution of single cells and individual virions.
    1. Medicine

    Inference from longitudinal laboratory tests characterizes temporal evolution of COVID-19-associated coagulopathy (CAC)

    Colin Pawlowski et al.
    Longitudinal laboratory testing results tied to SARS-CoV-2 diagnostic PCR results of more than 2500 patients reveal the temporal evolution of COVID-associated coagulopathy.

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