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    1. Epidemiology and Global Health
    2. Immunology and Inflammation

    Science Forum: A Global lmmunological Observatory to meet a time of pandemics

    Michael J Mina, C Jessica E Metcalf ... Bryan T Grenfell
    The COVID-19 pandemic has clearly demonstrated the need for a global system to monitor the dynamics of susceptibility and immunity, as well as infection, during epidemics and pandemics.
    1. Developmental Biology

    Motor neurons are dispensable for the assembly of a sensorimotor circuit for gaze stabilization

    Dena Goldblatt, Basak Rosti ... David Schoppik
    An analysis of vestibular projection neurons lacking their motor neuron partners resolves outstanding controversies for whether and how motor neurons shape vestibulo-ocular reflex circuit assembly.
    1. Epidemiology and Global Health

    Impact of seasonal variations in Plasmodium falciparum malaria transmission on the surveillance of pfhrp2 gene deletions

    Oliver John Watson, Robert Verity ... Hannah C Slater
    The timing of surveillance for pfhrp2/3-deletions within a transmission season impacts estimates of the proportion of false-negative RDTs due to deletions, which may cause premature decisions to change RDT.
    1. Epidemiology and Global Health

    Asymptomatic Bordetella pertussis infections in a longitudinal cohort of young African infants and their mothers

    Christopher J Gill, Christian E Gunning ... Pejman Rohani
    Longitudinal qPCR-based pertussis surveillance of a low-resource African cohort reveals frequent asymptomatic pertussis infections in both young infants and mothers and suggests possible early warning signals for epidemic outbreaks.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin

    Morgan Levine, Ross A McDevitt ... Luigi Ferrucci
    The first epigenetic clock for rats was developed and revealed to reflect phenotypic aging and captured the effects of longevity interventions.
    1. Medicine

    Characterization and prediction of clinical pathways of vulnerability to psychosis through graph signal processing

    Corrado Sandini, Daniela Zöller ... Stephan Eliez
    A novel methodical approach aimed at improving translation of network analyses to psychopathology provides an intuitive representation of longitudinal clinical pathways between symptoms and can assist in predicting prognosis.
    1. Evolutionary Biology

    Privatisation rescues function following loss of cooperation

    Sandra Breum Andersen, Melanie Ghoul ... Ashleigh S Griffin
    A population of pathogenic bacteria is found to respond to the loss of cooperation by privatising an essential function.
    1. Genetics and Genomics
    2. Neuroscience

    Propensity for somatic expansion increases over the course of life in Huntington disease

    Radhia Kacher, François-Xavier Lejeune ... Alexandra Durr
    Somatic instability of the CAG repeat increases progressively with age and disease progression in Huntington disease mutation carriers, starting with low levels in fetal brain tissues.
    1. Neuroscience

    A robust brain network for sustained attention from adolescence to adulthood that predicts later substance use

    Yihe Weng, Johann Kruschwitz ... IMAGEN Consortium
    Differences in behavior and brain connectivity in young adolescents predicted future substance use.
    1. Epidemiology and Global Health
    2. Medicine

    Antibody levels following vaccination against SARS-CoV-2: associations with post-vaccination infection and risk factors in two UK longitudinal studies

    Nathan J Cheetham, Milla Kibble ... Claire J Steves
    Third SARS-CoV-2 vaccination appears to eliminate disparities in anti-Spike antibodies between those who received Pfizer-BioNTech versus Oxford/AstraZeneca for first and second vaccination, but levels remain lower in certain groups such as those on the UK 'Shielded Patient List'.