3,254 results found
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Chromosome organization by one-sided and two-sided loop extrusion

    Edward J Banigan et al.
    Seemingly contradictory findings of single-molecule and in vivo experiments on a major mechanism of chromosome organization are reconciled by computationally investigating mechanisms of loop extrusion that are consistent with both.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Defining the location of promoter-associated R-loops at near-nucleotide resolution using bisDRIP-seq

    Jason G Dumelie, Samie R Jaffrey
    Genome-wide profiling of R-loops at near single-nucleotide resolution reveals distinct R-loop boundaries depending on the presence and location of the first exon-intron junction.
    1. Chromosomes and Gene Expression

    Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage

    Caroline Townsend Stork et al.
    The transcriptional response elicited by the hormone estrogen leads to DNA double-strand breaks by promoting R-loop formation in breast cancer cells.
    1. Biochemistry and Chemical Biology

    CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks

    Joshua C Cofsky et al.
    The DNA flanks on either side of an R-loop differ in stability, and CRISPR-Cas12 enzymes form double-strand breaks by targeting the more unstable flank with their single DNase active site.
    1. Chromosomes and Gene Expression

    RNase H enables efficient repair of R-loop induced DNA damage

    Jeremy D Amon, Douglas Koshland
    In addition to causing DNA damage, R-loops cause genomic instability by interfering with DNA repair.
    1. Cell Biology

    Evidence that a positive feedback loop drives centrosome maturation in fly embryos

    Ines Alvarez-Rodrigo et al.
    Polo kinase recruitment by the protein Spd-2 to the pericentriolar scaffold is a key element of the positive feedback loop which drives the expansion of the mitotic centrosomes in flies.
    1. Neuroscience

    Analogue closed-loop optogenetic modulation of hippocampal pyramidal cells dissociates gamma frequency and amplitude

    Elizabeth Nicholson et al.
    Neurons can synchronize, supporting flexible communication among brain areas; closed-loop optogenetics allows the frequency and power of population oscillations to be dissociated, providing a tool to interrogate how networks couple.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Cohesin and condensin extrude DNA loops in a cell cycle-dependent manner

    Stefan Golfier et al.
    Reconstitution of DNA loop extrusion in cellular contexts using Xenopus egg extracts shows that condensin extrudes DNA loops non-symmetrically in metaphase, whereas cohesin extrudes DNA loops symmetrically in interphase.
    1. Structural Biology and Molecular Biophysics

    Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA

    Ruobo Zhou et al.
    Analyzing single molecules reveals that Pif1 family helicases periodically patrol DNA, which may explain this enzyme's ability to suppress genome instability at G-quadruplex motifs and transcriptional RNA-DNA hybrids (R-loops).
    1. Cell Biology

    A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory

    Rebecca S Mathew et al.
    A fear conditioning-induced miRNA acts in a negative feedback loop that targets vesicle exocytosis and neurotransmitter receptor trafficking, and inhibits memory formation.

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