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    1. Evolutionary Biology
    2. Neuroscience

    Diversity and evolution of cerebellar folding in mammals

    Katja Heuer, Nicolas Traut ... Roberto Toro
    A computational neuroanatomy analysis of cerebellar and cerebral folding in 56 mammalian species reveals groups of highly variable 'diverse' phenotypes, and strongly conserved 'stable' phenotypes, providing new insights into the diversity, evolution, and influence of cortical folding on brain organisation.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    The imprinted Zdbf2 gene finely tunes control of feeding and growth in neonates

    Juliane Glaser, Julian Iranzo ... Deborah Bourc'his
    Zdbf2 is a paternally expressed gene that is mainly expressed in the hypothalamus and promotes appetite and body weight gain in neonates.
    1. Genetics and Genomics
    2. Neuroscience

    Machine learning sequence prioritization for cell type-specific enhancer design

    Alyssa J Lawler, Easwaran Ramamurthy ... Andreas R Pfenning
    A new cross-species machine learning-based strategy is applied to find enhancers that specifically label parvalbumin neurons in the mouse and macaque.
    1. Neuroscience

    Human hippocampal CA3 damage disrupts both recent and remote episodic memories

    Thomas D Miller, Trevor T-J Chong ... Clive R Rosenthal
    Human hippocampal cornu ammonis 3 damage impairs both recent and remote autobiographical episodic memory, and disrupts functional integration in medial temporal lobe subsystem regions of the default network.
    1. Physics of Living Systems
    2. Cell Biology

    Cortical flow aligns actin filaments to form a furrow

    Anne-Cecile Reymann, Fabio Staniscia ... Stephan W Grill
    Compressing the actomyosin network by cortical flow causes filaments to align and form a constricting ring.
    1. Structural Biology and Molecular Biophysics

    STIM1-dependent peripheral coupling governs the contractility of vascular smooth muscle cells

    Vivek Krishnan, Sher Ali ... Scott Earley
    STIM1 regulates the contractility of blood vessels and blood pressure by organizing membrane contact sites and ion channel activity in vascular smooth muscle cells in a manner that is independent of its canonical function in store-operated Ca2+entry.
    1. Immunology and Inflammation
    2. Neuroscience

    T cells modulate the microglial response to brain ischemia

    Corinne Benakis, Alba Simats ... Arthur Liesz
    Transcriptional signature and cell morphology of the stroke-associated microglia are reprogrammed by distinct T cell subpopulations.
    1. Cell Biology
    2. Developmental Biology

    Human embryo polarization requires PLC signaling to mediate trophectoderm specification

    Meng Zhu, Marta Shahbazi ... Magdalena Zernicka Goetz
    Functional analyses of in vitro fertilized, preimplanation human embryos reveal that the first lineage segregation depends on cell polarization signaling that is regulated by Phospholipase C (PLC) activity.
    1. Stem Cells and Regenerative Medicine

    Stress responsive miR-31 is a major modulator of mouse intestinal stem cells during regeneration and tumorigenesis

    Yuhua Tian, Xianghui Ma ... Zhengquan Yu
    miR-31 drives proliferation of intestinal stem cells, and protects intestinal stem cells against apoptosis both during homeostasis and regeneration in response to ionizing radiation injury, and promotes intestinal tumorigenesis through regulation of multiple signaling pathways.
    1. Genetics and Genomics
    2. Neuroscience

    Layered roles of fruitless isoforms in specification and function of male aggression-promoting neurons in Drosophila

    Margot Wohl, Kenichi Ishii, Kenta Asahina
    Male-type aggressive and courtship behaviors of the fruit flies are differentially specified by two sex-determining genes, providing a substrate for the evolution to sculpt these two behaviors independently.