6,900 results found
    1. Medicine

    Meta-Research: A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals

    Diana Herrera-Perez et al.
    An analysis of more than 3000 randomized controlled trials published in JAMA, the Lancet and NEJM has identified 396 medical reversals.
    1. Neuroscience

    Midbrain dopamine neurons signal aversion in a reward-context-dependent manner

    Hideyuki Matsumoto et al.
    Dopamine neurons signal value prediction errors (VPEs) integrating information about both reward and aversion, in low reward contexts, whereas VPEs in some dopamine neurons are distorted in high reward contexts.
  1. Research Culture: Framework for advancing rigorous research

    Walter J Koroshetz et al.
    Establishing a community of 'rigor champions' and building a comprehensive educational platform to teach the principles of rigorous science will help to ensure that the outputs of scientific research remain reliable and robust.
    1. Microbiology and Infectious Disease

    Transcriptomics: Revisiting the genomes of herpesviruses

    Bhupesh K Prusty, Adam W Whisnant
    Combining integrative genomics and systems biology approaches has revealed new and conserved features in the genome of human herpesvirus 6.
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    1. Computational and Systems Biology

    Science Forum: Wikidata as a knowledge graph for the life sciences

    Andra Waagmeester et al.
    Wikidata is continuously-updated resource that could improve the efficiency and accuracy of research in many areas of the life and biomedical sciences.
    1. Computational and Systems Biology
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    Meta-Research: Releasing a preprint is associated with more attention and citations for the peer-reviewed article

    Darwin Y Fu, Jacob J Hughey
    An analysis of more than 70,000 journal articles, including 5405 that were first released as a preprint on bioRxiv, shows that articles with a preprint received 49% more attention and 36% more citations than articles without one.
    1. Cell Biology
    2. Developmental Biology

    Philosophy of Biology: The analysis of living systems can generate both knowledge and illusions

    Antony M Jose
    By thinking about experimental techniques in terms of six broad approaches – perturbation, visualization, substitution, characterization, reconstitution, and simulation – researchers may be able to generate more reliable inferences.

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