5,444 results found
    1. Structural Biology and Molecular Biophysics

    Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity

    Zhijie Lin et al.
    A systematic and quantitative investigation showing how highly specific WW domain-mediated protein-protein interaction network is organized in cell growth and polarity.
    1. Evolutionary Biology
    2. Plant Biology

    Natural selection and repeated patterns of molecular evolution following allopatric divergence

    Yibo Dong et al.
    The genomic architecture of allopatric species is a mosaic of many conserved genes and a few adaptive ones, reflecting balance between conservation of ancestral functions and evolution of new features.
    1. Developmental Biology
    2. Evolutionary Biology

    The alternative regenerative strategy of bearded dragon unveils the key processes underlying vertebrate tooth renewal

    Lotta Salomies et al.
    Analysis of bearded dragon model reveals a novel tooth replacement strategy that demonstrates the critical importance of epithelial patterning, cell migration, and putative stem cell functional specialization in tissue regeneration.
    1. Structural Biology and Molecular Biophysics

    High-resolution and high-accuracy topographic and transcriptional maps of the nucleosome barrier

    Zhijie Chen et al.
    Direct observation of RNA Polymerase II transcription through a single nucleosome at near basepair resolution suggests a mechanism for selective control of gene expression.
    1. Cell Biology

    Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1

    David F Moreno et al.
    Cells accumulate damaged proteins during aging and, by compromising the function of chaperones in folding newly synthesized G1 cyclins, proteostasis breakdown inhibits cell-cycle entry and drives yeast cells into senescence.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B

    Timo Vögtle et al.
    Heparan sulfates in the vessel wall bind and regulate signaling from the megakaryocyte/platelet-specific inhibitory receptor G6b-B, a critical regulator of platelet homeostasis.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structural state recognition facilitates tip tracking of EB1 at growing microtubule ends

    Taylor A Reid et al.
    EB1 targeting to growing microtubule plus-ends is facilitated by tapered microtubule tip structures.
    1. Physics of Living Systems

    Surface-to-volume scaling and aspect ratio preservation in rod-shaped bacteria

    Nikola Ojkic et al.
    Rod-shaped bacteria preserve their aspect ratios and surface-to-volume scaling by maintaining a homeostatic balance between the rates of cell elongation and division protein synthesis.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Extensive ribosome and RF2 rearrangements during translation termination

    Egor Svidritskiy et al.
    Ensemble cryo-EM visualizes how structural rearrangements poise the newly made protein and release factor RF2 to dissociate in preparation for ribosome recycling.
    1. Microbiology and Infectious Disease

    Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation

    Myra Hosmillo et al.
    A key cellular stress granule protein, G3BP1, is critical for efficient norovirus infection, representing the first pan-norovirus, pro-viral factor identified to date.

Refine your results by:

Type
Research categories