A Drosophila olfactory circuit exhibits experience-dependent glial pruning during a well-defined critical period, with long-term consequences for odor processing.

Crispant analysis in zebrafish serves as a powerful tool for the rapid functional screening of genes implicated in bone fragility disorders, like osteogenesis imperfecta and osteoporosis.

Breast luminal epithelial cells are the hotspots of aging-associated changes, which prime aged epithelia for oncogenic gene activation and may explain individual differences in breast cancer susceptibility due to the aging-associated increase in gene expression variances in luminal epithelia.

Biophysical binding and structural prediction studies reveal that Tetraspanin12 directly binds the ligand Norrin, in a manner that is negatively cooperative with Norrin-Fzd4 binding and competitive with Norrin-LRP5/6 binding.

Short-term interventions, including intermittent fasting, boosting cellular energy, and promoting beneficial gut bacteria, rejuvenate osteoprogenitors in aged animals and, when combined with localized Wnt, restore youthful bone healing.