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    1. Neuroscience

    Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration

    Kuchuan Chen et al.
    In Drosophila, the loss of Frataxin causes iron accumulation in the nervous system, which in turn enhances sphingolipid synthesis and activation of PDK1 and Mef2, which leads to neurodegeneration.
    1. Cell Biology
    2. Human Biology and Medicine

    The mammalian lectin galectin-8 induces RANKL expression, osteoclastogenesis, and bone mass reduction in mice

    Yaron Vinik et al.
    The secreted sugar-binding protein galectin-8 causes osteoblasts to secrete factors that promote the differentiation of bone marrow cells into osteoclasts; targeting this protein could therefore potentially help treat diseases associated with excessive bone loss.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The ATPases of cohesin interface with regulators to modulate cohesin-mediated DNA tethering

    Gamze Çamdere et al.
    A critical second step in DNA tethering by cohesin occurs after its stable binding to DNA, and this second step is modulated by the Smc3 ATPase active site in Saccharomyces cerevisiae.
    1. Microbiology and Infectious Disease

    Kin cell lysis is a danger signal that activates antibacterial pathways of Pseudomonas aeruginosa

    Michele LeRoux et al.
    The death of bacterial kin cells releases a danger signal that activates a posttranscriptional response in surviving cells, resulting in the rapid elaboration of interbacterial competition factors.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy

    Stefan Heinrichs et al.
    Reduced expression of MYBL2 contributes to malignancies of the blood by permitting uncontrolled expansion of blood cell progenitors, implying a tumor suppressor function for this gene.
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    Robo2 acts in trans to inhibit Slit-Robo1 repulsion in pre-crossing commissural axons

    Timothy A Evans et al.
    The Roundabout2 receptor acts non-autonomously to promote commissural axons to cross the midline by antagonizing Slit-dependent axon repulsion.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing

    Sunbin Liu et al.
    Structural and functional analyses show how the spliceosomal Prp3 protein concomitantly binds double- and single- stranded regions in U4/U6 di-snRNAs and serves to stabilize the U4/U6•U5 tri-snRNP for splicing.
    1. Plant Biology

    Host-induced bacterial cell wall decomposition mediates pattern-triggered immunity in Arabidopsis

    Xiaokun Liu et al.
    Arabidopsis lysozyme LYS1 generates soluble peptidoglycan fragments to mediate pattern-triggered immunity.
    1. Developmental Biology and Stem Cells

    Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron

    Nils O Lindström et al.
    The patterning of the nephron is driven by a gradient in the activity of β-catenin and further defined by a network of BMP, PTEN and NOTCH signalling.
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    Delivery of circulating lipoproteins to specific neurons in the Drosophila brain regulates systemic insulin signaling

    Marko Brankatschk et al.
    Yeast specific lipids promote the transport of lipid transfer protein (LTP) across the blood brain barrier to the neurons that regulate systemic insulin signaling.