1,251 results found
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Asynchrony between virus diversity and antibody selection limits influenza virus evolution

    Dylan H Morris, Velislava N Petrova ... Colin A Russell
    Despite the virus' error prone polymerase, influenza virus antigenic evolution is rare, even in previously immune hosts, virus replication occurs before producing new antibodies.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity

    Wenlei Ye, Tina W Han ... Lily Yeh Jan
    TMEM16F shifts its ion selectivity in response to change of intracellular Ca2+, membrane potential and ionic strength.
    1. Neuroscience

    The tetraspanin TSPAN5 regulates AMPAR exocytosis by interacting with the AP4 complex

    Edoardo Moretto, Federico Miozzo ... Maria Passafaro
    In mature neurons, TSPAN5 assembles into a complex with AP4 and Stargazin to promote the exocytosis of AMPA receptors.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes

    Michelle C Ward, Nicholas E Banovich ... Yoav Gilad
    Cellular stress in a disease-relevant cell type uncovers novel genetic effects on gene expression, which is likely relevant for disease.
    1. Developmental Biology
    2. Genetics and Genomics

    Feedback between a retinoid-related nuclear receptor and the let-7 microRNAs controls the pace and number of molting cycles in C. elegans

    Ruhi Patel, Himani Galagali ... Alison R Frand
    A genetic oscillator composed of NHR-23 and let-7 family of microRNAs links the molting cycle timer and the heterochronic pathway to regulate the pace of molting in C. elegans and ensure that worms molt only four times.
    1. Developmental Biology
    2. Neuroscience

    Expansion microscopy of C. elegans

    Chih-Chieh (Jay) Yu, Nicholas C Barry ... Edward S Boyden
    Fixed, intact animals of C. elegans can be physically expanded with high isotropy, to enable super-resolved imaging of general proteins and nucleic acids throughout the organism, on conventional microscopes.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Investigating molecular crowding within nuclear pores using polarization-PALM

    Guo Fu, Li-Chun Tu ... Siegfried M Musser
    The super-resolution fluorescence microscopy approach polarization PALM (p-PALM) reveals that macromolecular crowding and inhomogeneity within nuclear pores generate a structurally and dynamically complex permeability barrier.
    1. Neuroscience

    Microprism-based two-photon imaging of the mouse inferior colliculus reveals novel organizational principles of the auditory midbrain

    Baher A Ibrahim, Yoshitaka Shinagawa ... Daniel A Llano
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Developmental Biology
    2. Neuroscience

    Microtubule networks in zebrafish hair cells facilitate presynapse transport and fusion during development

    Saman Hussain, Katherine Pinter ... Katie Kindt
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Binary and analog variation of synapses between cortical pyramidal neurons

    Sven Dorkenwald, Nicholas L Turner ... H Sebastian Seung
    Sizes of synapses between layer 2/3 pyramidal cells in mouse primary visual cortex are well modeled by the sum of a binary variable and an analog variable drawn from a log-normal distribution.

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