Chloe Santos, Abigail R Marshall ... Andrew J Copp
Analysis of 108 human embryos aged 3–7 weeks reveals modes of primary and secondary neurulation, regulation of body elongation, somite formation rate, and common occurrence of a split neural tube.
Charles F Ericson, Fabian Eisenstein ... Nicholas J Shikuma
Bacteria produce a syringe-like structure, loaded with a single protein within the lumen of its needle-like tube, that is sufficient for stimulating animal metamorphosis.
Synergistic interactions with PI(4,5)P2 and activated Rho1, which are enriched at the apical membrane of tubular organs, facilitate tight apical targeting of the formin Diaphanous.
Kishore R Mosaliganti, Ian A Swinburne ... Sean G Megason
Size regulation of the otic vesicle, the progenitor of the inner ear, is mediated by mechanical feedback involving fluid influx, hydraulic pressure, and tissue mechanics.
ATP enters the endoplasmic reticulum (ER) lumen through an SLC35B1/AXER-dependentCaATiER mechanism, and ATP usage in the ER renders 'anti-Warburg' effect by increasing ATP regeneration from OxPhos while decreasing glycolysis.
Wenchang Zhou, Fabrizio Marinelli ... José D Faraldo-Gómez
The notion that the lumen of the ATP synthase membrane rotor is the long-sought megachannel that triggers the onset of the mitochondrial permeability transition is found to be inconsistent with its actual structural and functional properties.
Sumeda Nandadasa, Jason M Szafron ... Suneel S Apte
Morphologic, molecular, biomechanical and computational analyses show that the specialized extracellular matrix architecture of the umbilical artery contributes to its rapid closure at birth and regulates smooth muscle cell differentiation.
Disrupting extrusion, a process that drives epithelial cell death, leads to increased cell survival, poor barrier function, and enhanced cell invasion and, thereby, promotes tumor initiation and progression.
