Improved characterisation of human embryonic lung development highlights human-mouse differences and facilitates the development of defined culture conditions for the expansion of self-renewing, multipotent human lung epithelial progenitor cells.
The control of local cell properties such as epithelial cell number and mechanical force production by Hippo signaling is a major determinant of lung branching.
The transcription factor CrebB mediates long-term memory formation in different neurons within the mushroom body learning circuit, including mushroom body intrinsic and output neurons but not dopaminergic input neurons.
Motor training decreased the unit synaptic response and suppressed induction of long-term depression at parallel fiber to Purkinje cell synapses in the cerebellum, supporting involvement of long-term depression in motor learning.
Behavioral and synaptic investigations of long-term memory in Aplysia reveal differing roles for DNA methylation, protein synthesis during training and protein synthesis shortly after training with respect to memory consolidation and maintenance.
A recurrent reward circuit in Drosophila, comprised of specific dopamine neurons and a single class of mushroom body output neurons, transforms a nascent memory trace into a stable long-term memory.
Lineage specifiers FoxA1 and FoxA2 control lung cancer growth and identity by activating gastric differentiation and suppressing squamous cell carcinoma transdifferentiation.
