6,158 results found
    1. Stem Cells and Regenerative Medicine
    2. Human Biology and Medicine

    Organ Development: Tips from the embryonic lung

    Avinash Waghray, Jayaraj Rajagopal
    A new source of progenitor cells can now be used to study hidden aspects of human lung development and pediatric lung disease.
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    1. Stem Cells and Regenerative Medicine
    2. Human Biology and Medicine

    Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids

    Marko Z Nikolić et al.
    Improved characterisation of human embryonic lung development highlights human-mouse differences and facilitates the development of defined culture conditions for the expansion of self-renewing, multipotent human lung epithelial progenitor cells.
    1. Developmental Biology

    YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis

    Chuwen Lin et al.
    The control of local cell properties such as epithelial cell number and mechanical force production by Hippo signaling is a major determinant of lung branching.
    1. Neuroscience

    Multiple neurons encode CrebB dependent appetitive long-term memory in the mushroom body circuit

    Yves F Widmer et al.
    The transcription factor CrebB mediates long-term memory formation in different neurons within the mushroom body learning circuit, including mushroom body intrinsic and output neurons but not dopaminergic input neurons.
    1. Neuroscience

    Reinstatement of long-term memory following erasure of its behavioral and synaptic expression in Aplysia

    Shanping Chen et al.
    Storage of long-term memory in Aplysia does not require stable synapses.
    1. Neuroscience

    Occurrence of long-term depression in the cerebellar flocculus during adaptation of optokinetic response

    Takuma Inoshita, Tomoo Hirano
    Motor training decreased the unit synaptic response and suppressed induction of long-term depression at parallel fiber to Purkinje cell synapses in the cerebellum, supporting involvement of long-term depression in motor learning.
    1. Cancer Biology

    KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer

    Elsa B Krall et al.
    Loss of KEAP1 modulates sensitivity to targeted therapies in lung cancer.
    1. Neuroscience

    Role of protein synthesis and DNA methylation in the consolidation and maintenance of long-term memory in Aplysia

    Kaycey Pearce et al.
    Behavioral and synaptic investigations of long-term memory in Aplysia reveal differing roles for DNA methylation, protein synthesis during training and protein synthesis shortly after training with respect to memory consolidation and maintenance.
    1. Neuroscience

    Reward signal in a recurrent circuit drives appetitive long-term memory formation

    Toshiharu Ichinose et al.
    A recurrent reward circuit in Drosophila, comprised of specific dopamine neurons and a single class of mushroom body output neurons, transforms a nascent memory trace into a stable long-term memory.
    1. Cancer Biology

    FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer

    Soledad A Camolotto et al.
    Lineage specifiers FoxA1 and FoxA2 control lung cancer growth and identity by activating gastric differentiation and suppressing squamous cell carcinoma transdifferentiation.

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