186 results found
  1. August 2015

    Episode 22: August 2015

    In this episode we hear about cancer, dengue fever, sperm DNA and neurons that are sensitive to magnetic fields.
    1. Cancer Biology
    Reproducibility Project

    Reproducibility Project: Cancer Biology

    Edited by Roger J Davis et al.
    Investigating reproducibility in preclinical cancer research.
    1. Cancer Biology

    Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts

    Tushar D Bhagat et al.
    Lactate in pancreatic cancer micro-environment can lead to TET enzyme activation and loss of DNA methylation seen in cancer associated fibroblasts.
    1. Cell Biology

    The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation

    Tsung-Chieh Lin et al.
    NIFK promotes lung cancer metastasis via Runx1-dependent repression of CK1α, which activates TCF4/β-catenin signaling.
    1. Cell Biology
    2. Cancer Biology

    SPOP mutation leads to genomic instability in prostate cancer

    Gunther Boysen et al.
    SPOP mutations underlie a novel, genomically unstable subclass of prostate cancer by altering DNA repair.
    1. Cancer Biology

    Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

    Zeyad D Nassar et al.
    DECR1, a rate-limiting enzyme for polyunsaturated fatty acid (PUFA) β-oxidation, is an androgen-repressed gene in prostate cancer cells that limits oxidative stress to promote cancer cell survival.
    1. Cancer Biology
    2. Cell Biology

    LAST, a c-Myc-inducible long noncoding RNA, cooperates with CNBP to promote CCND1 mRNA stability in human cells

    Limian Cao et al.
    A c-Myc-transcribed long noncoding RNA namely LAST (LncRNA-assisted stabilization of transcripts) collaborates with a cellular factor CNBP to promote the stability of CCND1/cyclin D1 mRNA post-transcriptionally, ensuring the proper G1/Sphase transition of the cell cycle.
    1. Cancer Biology

    Co-targeting the tumor endothelium and P-selectin-expressing glioblastoma cells leads to a remarkable therapeutic outcome

    Shiran Ferber et al.
    Treatment with precision nanomedicine in combination with an anti-angiogenic peptide enhance anti-tumor efficacy while minimizing toxicities in a pre-clinical glioblastoma model, making this approach a promising and important therapeutic alternative for patients.
    1. Cell Biology
    2. Cancer Biology

    BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function

    Xuetian Yue et al.
    Overexpression of BAG2—a novel mutant p53 binding protein—in tumors inhibits MDM2-mediated mutant p53 degradation, which leads to the accumulation of mutant p53 protein and promotes tumorigenesis.
    1. Genetics and Genomics
    2. Cancer Biology

    Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

    Young Seok Ju et al.
    Identifying 1,907 mitochondrial somatic mutations from 1,675 tumor tissues provides new insights into the causes and effects of the mitochondrial genome mutations found in human cancers.

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