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    1. Cancer Biology
    2. Immunology and Inflammation

    Discovery and Translation of Cancer Immunology: A Special Issue

    Edited by Jeffrey Settleman et al.
    eLife is pleased to present a Special Issue to highlight recent advances in the mechanistic understanding of the immune response to cancer cells.
  1. A series of articles on the philosophy of biology

    Philosophy of Biology

    Edited by Helga Groll
    A series of articles offering philosophical perspectives on the life sciences.
  2. Blue sound waves on black background

    Episode 63: January 2020

    In this episode we hear about a fall in average body temperature over time, how our brain encodes seasons, why members of underrepresented communities leave academia and more.
  3. Parents and children work together to build a tower of blocks that feature images representing work and family activities that a scientist may take part in

    Scientist and Parent

    Edited by Emma Pewsey et al.
    A research career and family life are not incompatible.
  4. Group of raised hands

    Episode 61: October 2019

    In this episode we hear about parents passing on new mutations, a genetic mystery 100 years in the making, the experiences of early-career group leaders, and more.
    1. Chromosomes and Gene Expression
    2. Cell Biology

    Aging, Geroscience and Longevity: A Special Issue

    Edited by Matt Kaeberlein et al.
    eLife is pleased to present a Special Issue to highlight recent advances in the mechanistic understanding of aging and interventions that extend longevity.
    1. Developmental Biology
    2. Plant Biology

    A digital 3D reference atlas reveals cellular growth patterns shaping the Arabidopsis ovule

    Athul Vijayan et al.
    Deep imaging, machine-learning-based segmentation, and tissue annotation resulted in a developmental series of 3D digital ovules with cellular resolution allowing next-level analysis of the ontogenesis of this complex organ.
    1. Chromosomes and Gene Expression

    Sustained TNF-α stimulation leads to transcriptional memory that greatly enhances signal sensitivity and robustness

    Zuodong Zhao et al.
    Sustained TNF-α induction consolidates transcriptional memory for faster, stronger, and more sensitive subsequent induction in an active DNA demethylation-dependent manner for memory genes including CALCB, a therapeutic target for migraine.
    1. Biochemistry and Chemical Biology

    Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection

    Donghyuk Shin et al.
    A novel class of bacterial OTU deubiquitinases provides insights on the distinct roles of bacterial deubiquitinases in host–pathogen interactions.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    The deubiquitylase Ubp15 couples transcription to mRNA export

    Fanny Eyboulet et al.
    Ubp15 regulates the ubiquitylation of the export adaptor Mex67.