1,053 results found
    1. Cell Biology
    2. Human Biology and Medicine

    Automated cell-type classification in intact tissues by single-cell molecular profiling

    Monica Nagendran et al.
    The ability to rapidly stain for any combination of genes in intact tissue with automated quantification of transcripts in individual cells and spatial re-mapping affords new insights into lung biology, and will greatly accelerate progress in scientific and medical research.
    1. Microbiology and Infectious Disease

    Research: A comprehensive and quantitative exploration of thousands of viral genomes

    Gita Mahmoudabadi, Rob Phillips
    A compendium of critical genomic numbers for viruses through the lenses of different viral classification systems.
    1. Cell Biology
    2. Computational and Systems Biology

    Science Forum: The Human Cell Atlas

    Aviv Regev et al.
    Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
    1. Ecology
    2. Human Biology and Medicine

    Point of View: A transatlantic perspective on 20 emerging issues in biological engineering

    Bonnie C Wintle et al.
    Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.
  1. Research: Decoupling of the minority PhD talent pool and assistant professor hiring in medical school basic science departments in the US

    Kenneth D Gibbs Jr et al.
    A systems-level analysis of the biomedical workforce in the US shows that current strategies to enhance faculty diversity are unlikely to have a significant impact, and that there is a need to increase the number of PhDs from underrepresented minority backgrounds who move on to postdoctoral positions.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Science Forum: Viral factors in influenza pandemic risk assessment

    Marc Lipsitch et al.
    We identify key strengths and limitations in use of viral genotyping and phenotyping to estimate pandemic risk from influenza A viruses, focusing on 3 traits, hemagglutinin binding specificity, hemagglutinin pH of activation, and polymerase complex efficiency.
    1. Neuroscience

    Local processing in neurites of VGluT3-expressing amacrine cells differentially organizes visual information

    Jen-Chun Hsiang et al.
    Neurite arbors of VGluT3-expressing amacrine cells (VG3-ACs) process visual information locally uniformly detecting object motion while varying in contrast preferences; and in spite of extensive overlap between arbors of neighboring cells population activity in the VG3-AC plexus encodes stimulus positions with subcellular precision.
    1. Neuroscience

    Risk of punishment influences discrete and coordinated encoding of reward-guided actions by prefrontal cortex and VTA neurons

    Junchol Park, Bita Moghaddam
    Risk of punishment during reward seeking behavior is associated with a functional "disconnection" of the PFC-VTA circuit due to a transient loss of VTA-driven theta oscillation.
    1. Cancer Biology

    Diagnostic potential for a serum miRNA neural network for detection of ovarian cancer

    Kevin M Elias et al.
    Application of machine learning to serum miRNA profiles generated through next generation sequencing identifies a biologically relevant miRNA signature which can be deployed as a qPCR test to assist the diagnosis of epithelial ovarian cancer.
    1. Chromosomes and Gene Expression

    Cooperative interactions enable singular olfactory receptor expression in mouse olfactory neurons

    Kevin Monahan et al.
    Biochemical and genetic experiments show that Ebf and Lhx2 cooperate to specify olfactory receptor enhancers, which cooperate to drive olfactory receptor expression.

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