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    1. Cancer Biology
    2. Cell Biology

    The eukaryotic translation initiation factor eIF4E harnesses hyaluronan production to drive its malignant activity

    Hiba Ahmad Zahreddine et al.
    The eukaryotic translation initiation factor eIF4E induces hyaluronic acid (HA) synthesis to drive cancer metastasis which can be reversed following eIF4E inhibition and HA degradation.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    De-repression of the RAC activator ELMO1 in cancer stem cells drives progression of TGFβ-deficient squamous cell carcinoma from transition zones

    Heather A McCauley et al.
    A new mechanism connects the loss of TGFβ signaling with invasion and metastasis in highly malignant transition zone tumors.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Topological signatures in regulatory network enable phenotypic heterogeneity in small cell lung cancer

    Lakshya Chauhan et al.
    Network topology and gene expression patterns in small cell lung cancer reveal two mutually opposing teams of regulators that enable multistability and consequent non-genetic heterogeneity, a clinically unsolved challenge.
    1. Cancer Biology

    MYC and Twist1 cooperate to drive metastasis by eliciting crosstalk between cancer and innate immunity

    Renumathy Dhanasekaran et al.
    MYC and Twist1 drive metastasis by a novel non-cell-autonomous transcriptional mechanism of eliciting a cytokinome that mediates the crosstalk between cancer cells and macrophages, and its therapeutic blockade inhibits metastasis.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins

    Alexander J Martinko et al.
    Proteomics and functional genomics coupled to an antibody discovery pipeline revealed the influence of oncogenic RAS signaling on the cell-surface proteome and resulted in the discovery of potential therapeutic targets for RAS-driven cancers.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice

    Jeroen Overman et al.
    A novel molecular strategy to block transcription factor activity using small molecule interference of multiple protein-protein interactions is reported.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L

    Victoria E Pedanou et al.
    A large-scale RNA interference screen uncovers a new transcriptional regulatory program involving the histone H3 demethylase KDM3A, which mediates detachment-induced apoptosis (anoikis) in breast epithelial cells.
    1. Cancer Biology
    2. Cell Biology

    Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling

    Yingqi Liu et al.
    PRMT7-mediated SHANK2 methylation regulates breast cancer metastasis by activating endosomal FAK signals, and may provide potential clues for tumour metastasis treatment strategies.