805 results found
    1. Microbiology and Infectious Disease

    Respiratory tissue-associated commensal bacteria offer therapeutic potential against pneumococcal colonization

    Soner Yildiz et al.
    A respiratory tissue-associated commensal Lactobacillus strain confers colonization resistance to Streptococcus pneumoniae, when applied therapeutically in a post influenza virus super-infection model.
    1. Microbiology and Infectious Disease

    Gut microbiota density influences host physiology and is shaped by host and microbial factors

    Eduardo J Contijoch et al.
    The density of the gut microbiota influences the host immune system and adiposity, and can be therapeutically manipulated.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Consistent and correctable bias in metagenomic sequencing experiments

    Michael R McLaren et al.
    A mathematical model of bias in marker-gene and metagenomic sequencing measurements explains systematic errors in defined mixtures of microbial species, and enables quantitative and reproducible investigation of biological communities.
    1. Evolutionary Biology

    Resurrection of a global, metagenomically defined gokushovirus

    Paul C Kirchberger, Howard Ochman
    Isolation of a gokushovirus capable of lysogenizing enterobacteria challenges previous notions about the biology of the most prolific phages within the Microviridae and facilitates experimental study in a model organism.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    Host-associated microbe PCR (hamPCR) enables convenient measurement of both microbial load and community composition

    Derek S Lundberg et al.
    hamPCR is a cost-effective and transformative amplicon sequencing strategy to describe microbiota composition and measure its overall abundance, applicable to all samples in which host and microbial DNA are co-extracted.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3

    Francesco Beghini et al.
    The bioBakery 3 platform enables improved, integrated, and strain-level analysis of microbial communities from large-scale meta-omic data.
    1. Plant Biology

    Antimicrobial peptide expression in a wild tobacco plant reveals the limits of host-microbe-manipulations in the field

    Arne Weinhold et al.
    The attempt to manipulate a microbiome in planta to study the ecological consequences under field conditions leaves plants and their microbes surprisingly unimpressed.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Quantifying antibiotic impact on within-patient dynamics of extended-spectrum beta-lactamase resistance

    Rene Niehus et al.
    A data-driven within-host model reveals that different antibiotics are associated with divergent effects on antibiotic resistance carriage and abundance in hospitalised patients, with important implications for antibiotic stewardship.
    1. Computational and Systems Biology

    Trajectories of childhood immune development and respiratory health relevant to asthma and allergy

    Howard HF Tang et al.
    Unsupervised cluster analysis identified similar groups of children in different cohorts, with distinct developmental patterns of immunorespiratory health, asthma and allergy.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    Microbiota regulates visceral pain in the mouse

    Pauline Luczynski et al.
    Determining that microbiota-deficient mice have increased visceral pain, which can be reversed by restoring microbiota, may lead to novel microbial-based strategies for disorders associated with visceral pain.

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