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    1. Genetics and Genomics
    2. Immunology and Inflammation

    Single-cell analysis of mosquito hemocytes identifies signatures of immune cell subtypes and cell differentiation

    Hyeogsun Kwon, Mubasher Mohammed ... Ryan C Smith
    Single-cell RNA-seq analysis reveals an increased complexity of mosquito hemocytes, enabling the functional and molecular characterization of immune cell sub-populations in Anopheles gambiae.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response

    Pavla Nedbalova, Nikola Kaislerova ... Tomas Dolezal
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cancer Biology
    2. Cell Biology

    The scaffolding protein flot2 promotes cytoneme-based transport of wnt3 in gastric cancer

    Daniel Routledge, Sally Rogers ... Steffen Scholpp
    Signalling filopodia, also known as cytonemes, are a crucial transport mechanism of Wnt3 in gastric cancer and their emergence is controlled by Flot2.
    1. Developmental Biology
    2. Immunology and Inflammation

    Diverse homeostatic and immunomodulatory roles of immune cells in the developing mouse lung at single cell resolution

    Racquel Domingo-Gonzalez, Fabio Zanini ... Cristina M Alvira
    Single cell transcriptomics reveal a complex orchestration of lung immune cells during the transition from fetal to air-breathing life to fill context-specific functions in tissue remodeling, angiogenesis, and immunity.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Cryo-electron tomography of Birbeck granules reveals the molecular mechanism of langerin lattice formation

    Toshiyuki Oda, Haruaki Yanagisawa ... Tatsuyoshi Kawamura
    A honeycomb-lattice assembly within the skin and mucosa protects us from invading pathogens.
    1. Immunology and Inflammation

    Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells

    Dorothy K Sojka, Beatrice Plougastel-Douglas ... Wayne M Yokoyama
    Natural killer cells that were commonly thought to circulate around the body can actually reside in distinct tissues, such as in the liver, skin or uterus, and do not re-circulate.
    1. Immunology and Inflammation

    The role of B cells in immune cell activation in polycystic ovary syndrome

    Angelo Ascani, Sara Torstensson ... Elisabet Stener-Victorin
    Androgen receptor activation modifies B cell frequencies and functionality, accompanied by weight gain in female mice exposed to human PCOS IgG, highlighting the unrecognized involvement of B cells in PCOS autoimmune comorbidities despite their absence not preventing PCOS phenotype development.
    1. Immunology and Inflammation

    A humoral immune response to parasitoid wasps in Drosophila is regulated by JAK/STAT, NF-κB and GATA

    Shuyu Olivia Zhou, Jonathan P Day ... Francis M Jiggins
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Immunology and Inflammation

    Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema

    Ran You, Wen Lu ... Farrah Kheradmand
    The accumulation of carbon black nanoparticles in smokers' lungs causes sterile inflammation, double-strand DNA breaks and emphysema.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture

    Tangsheng Yi, Jason G Cyster
    The receptor EBI2 is essential for correctly positioning CD4+ dendritic cells in the spleen so that they can present blood-borne antigens to T cells and thereby provoke an antibody response.