A comprehensive molecular characterization of Schlemm’s canal cells to date provides a wealth of molecular details.

The lymphatic and blood network of the mouse epididymis in adulthood and during postnatal ontogeny has been analyzed in detail.

Novel and common angiogenic mechanisms crucial for fenestrated brain capillary formation have been identified.

Tie1 is a binding partner for Svep1 in zebrafish and humans, and both genes (but not Tie2) are required during zebrafish lymphangiogenesis especially for the facial lymphatics, which in part develop independent of Vegfc.

LncRNA Neat1, with paraspeckle proteins, controls translational induction of (lymph)angiogenic and cardioprotective factors by the IRES-dependent mechanism in mouse cardiomyocytes submitted to hypoxia.

While Dectin-1 is a well-known C-type lectin receptor recognizing b-glucan and involved in anti-fungal immunity, human Dectin-1 is O-glycosylated and acts as a ligand for another C-type lectin receptor, CLEC-2, expressed by platelets that mediates homeostatic responses such as lymphangiogenesis.

Zebrafish provide unique resources for the study of the tumor microenvironment.

Genetic lineage tracing reveals the cardiopharyngeal mesoderm as a cellular origin of craniofacial and cardiac lymphatic vessels, which most often affected in lymphatic malformation patients.