96 results found
    1. Cell Biology
    2. Developmental Biology

    EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity

    Maike Frye et al.
    EphrinB2/EphB4-mediated regulation of cytoskeletal contractility is a key homeostatic mechanism of lymphatic endothelial cell-cell junction maintenance, and provides a potential target for therapeutic modulation of lymphatic vessel permeability and function.
    1. Chromosomes and Gene Expression

    Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta

    Eric Engelbrecht et al.
    The sphingosine 1-phosphate receptor-1 (S1PR1) signals in heterogenous populations of mouse adventitial lymphatic (LEC) and arterial endothelial cells (aEC1, aEC2) to regulate chromatin and the transcriptome, thus affecting their phenotypes.
    1. Cancer Biology
    2. Cell Biology

    Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation

    Pirita Pekkonen et al.
    The melanoma cell interaction with lymphatic endothelial cells promotes melanoma metastasis by inducing a reversible switch to invasively sprouting melanoma cells.
    1. Developmental Biology

    Intracellular uptake of macromolecules by brain lymphatic endothelial cells during zebrafish embryonic development

    Max van Lessen et al.
    The discovery of a unique brain lymphatic cell type in the zebrafish model will facilitate the study of embryonic development and physiology, an essential mission to understand how clearance of macromolecules impact neurological diseases.
    1. Developmental Biology

    MicroRNA-mediated control of developmental lymphangiogenesis

    Hyun Min Jung et al.
    Lymphatic-enriched microRNA miR-204 is required for lymphatic development through its effects on the key lymphatic transcription factor NFATC1.
    1. Cell Biology
    2. Developmental Biology

    Shear stimulation of FOXC1 and FOXC2 differentially regulates cytoskeletal activity during lymphatic valve maturation

    Pieter R Norden et al.
    Genetic and molecular analyses show that FOXC1 and FOXC2 play a role in controlling lymphatic valve maintenance as key mediators of mechanotransduction to control cytoskeletal organization and RhoA/ROCK signaling.
    1. Cell Biology
    2. Immunology and Inflammation

    Molecular tracking devices quantify antigen distribution and archiving in the murine lymph node

    Shannon M Walsh et al.
    Antigen-phosphorothioate DNA conjugation provides a vaccination strategy where stable barcodes facilitate the detection and quantification of antigen using single-cell RNA sequencing.
    1. Cell Biology
    2. Medicine

    Lymphangiogenic therapy prevents cardiac dysfunction by ameliorating inflammation and hypertension

    LouJin Song et al.
    Lymphangiogenic therapy VEGFCc156s improved angiotensin-II-induced impairments in heart function via novel mechanisms, which include transcriptional responses to alleviate inflammation and cardiac fibrosis, and systemic responses to ameliorate hypertension.
    1. Cell Biology

    Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point

    Nicolas Baeyens et al.
    Flow-dependent remodeling of blood vessels is critical for normal physiology and for recovery from arterial blockage in disease; understanding its cellular mechanisms may lead to the development of treatments for patients that are deficient in this process following myocardial infarction or other vascular diseases.
    1. Developmental Biology

    Yap1 promotes sprouting and proliferation of lymphatic progenitors downstream of Vegfc in the zebrafish trunk

    Lin Grimm et al.
    Genetic studies reveal a role for Yap1 in lymphatic endothelial progenitor cell sprouting and proliferation during early zebrafish lymphatic vascular development.

Refine your results by:

Type
Research categories