Single-cell analysis of injured mouse sciatic nerves reveals rapid reprogramming of macrophages toward a glycolytic, proinflammatory phenotype during the early repair process.

Antitumor (natural killer) NK cell responses are negatively regulated by interactions between NK cells and endogenous NKG2D ligands constitutively expressed on lymph node endothelial cells and super-induced on tumor-associated endothelium.

Improved characterisation of human embryonic lung development highlights human-mouse differences and facilitates the development of defined culture conditions for the expansion of self-renewing, multipotent human lung epithelial progenitor cells.

Maps defining environmental risk of the leishmaniases provide insights into the ecology of these diseases and identify regions to target public health measures and inform future burden estimates.

Piezo1 functions as a key mechanotransducer for conferring mechanosensitivity to osteoblasts and determining mechanical-load-dependent bone formation, and represents a novel therapeutic target for treating osteoporosis or unloading-induced severe bone loss.

An increase in transcriptional noise generally assumed to characterize aged cells and tissues is shown to derive instead from technical and biological issues that underlie single-cell RNA sequencing experiments.

LncRNA Neat1, with paraspeckle proteins, controls translational induction of (lymph)angiogenic and cardioprotective factors by the IRES-dependent mechanism in mouse cardiomyocytes submitted to hypoxia.

Comparative studies of gene expression in the uterus during pregnancy identifies new genes important for pregnancy and associated with complications such as preterm birth.

Computational efforts yield a zebrafish transcriptome annotation that provides more sensitive and comprehensive gene detection over existing annotations when used for bulk or single-cell RNA-seq.