49 results found
    1. Neuroscience

    Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma

    Alex J Smith et al.
    Solute movement in brain extracellular space is determined by solute diffusion, and does not depend on convection or aquaporin-4 expression as predicted by the glymphatic mechanism.
    1. Human Biology and Medicine
    2. Neuroscience

    Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI

    Martina Absinta et al.
    Meningeal lymphatic vessels are present in human and nonhuman primates (common marmoset monkeys) and they can be noninvasively imaged and mapped in vivo with high-resolution, clinical MRI.
    1. Developmental Biology

    Intracellular uptake of macromolecules by brain lymphatic endothelial cells during zebrafish embryonic development

    Max van Lessen et al.
    The discovery of a unique brain lymphatic cell type in the zebrafish model will facilitate the study of embryonic development and physiology, an essential mission to understand how clearance of macromolecules impact neurological diseases.
    1. Cancer Biology
    2. Cell Biology

    Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation

    Pirita Pekkonen et al.
    The melanoma cell interaction with lymphatic endothelial cells promotes melanoma metastasis by inducing a reversible switch to invasively sprouting melanoma cells.
    1. Developmental Biology

    VEGF-C promotes the development of lymphatics in bone and bone loss

    Devon Hominick et al.
    Mice that overexpress VEGF-C in bone display a phenotype that resembles Gorham-Stout disease.
    1. Developmental Biology
    2. Neuroscience

    A novel perivascular cell population in the zebrafish brain

    Marina Venero Galanternik et al.
    A new brain perivascular cell type in the zebrafish related to mammalian Fluorescent Granular Perithelial (FGP) cells emerges directly from endothelium during early development.
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Immune Response: An ambulance for retinol

    Stephanie C Ganal, Andrew J MacPherson
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    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Tumor Angiogenesis: Taking aim at Sox18

    Injune Kim, Gou Young Koh
    A small molecule called Sm4 can disrupt interactions involving a transcription factor called Sox18, while having little impact on other members of the SoxF family.
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    1. Immunology and Inflammation

    Innate Like Lymphocytes: Moving at the frontline

    Marco Ataíde, Wolfgang Kastenmüller
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