301 results found
    1. Immunology and Inflammation
    2. Medicine

    Neutrophil-mediated fibroblast-tumor cell il-6/stat-3 signaling underlies the association between neutrophil-to-lymphocyte ratio dynamics and chemotherapy response in localized pancreatic cancer: A hybrid clinical-preclinical study

    Iago de Castro Silva, Anna Bianchi ... Jashodeep Datta
    A neutrophil-CAF-tumor cell IL-1β/IL-6/STAT-3 signaling axis in the pancreatic tumor microenvironment underlies the association between neutrophil-to-lymphocyte ratio dynamics and pathologic response in patients with pancreatic ductal adenocarcinoma undergoing neoadjuvant therapy.
    1. Immunology and Inflammation

    Cell-density independent increased lymphocyte production and loss rates post-autologous HSCT

    Mariona Baliu-Piqué, Vera van Hoeven ... Kiki Tesselaar
    Altered lymphocyte dynamics after hematopoietic stem cell transplantation cannot solely be explained by low lymphocyte numbers.
    1. Immunology and Inflammation

    Antigen receptor control of methionine metabolism in T cells

    Linda V Sinclair, Andrew JM Howden ... Doreen A Cantrell
    Antigen receptor control of methionine transport is critical to co-ordinate protein synthesis and the production of methyl donors for nucleotide and protein methylations which are required for T cell differentiation.
    1. Microbiology and Infectious Disease
    2. Immunology and Inflammation

    Cellular and molecular dynamics in the lungs of neonatal and juvenile mice in response to E. coli

    Sharon A McGrath-Morrow, Jarrett Venezia ... Alan L Scott
    A pre-clinical model of E. coli pneumonia reveals attenuated dynamics of MHCII-expressing mononuclear cells in neonatal lung associated with elevated susceptibility to bacterial pneumonia.
    1. Cell Biology
    2. Immunology and Inflammation

    Spatially resolved transcriptomics reveals pro-inflammatory fibroblast involved in lymphocyte recruitment through CXCL8 and CXCL10

    Ana J Caetano, Yushi Redhead ... Paul T Sharpe
    Integrated single-cell and spatial genomics provides the first molecular map of the human oral mucosa and reveals a novel pro-inflammatory fibroblast involved in disease progression.
    1. Ecology
    2. Microbiology and Infectious Disease

    Immune-mediated hookworm clearance and survival of a marine mammal decrease with warmer ocean temperatures

    Mauricio Seguel, Felipe Montalva ... Nicole Gottdenker
    In years with colder ocean temperatures, fur seal pups receive more maternal care and have a better energy balance, clearing hookworm infection earlier, which increases their chances of survival.
    1. Cell Biology
    2. Immunology and Inflammation

    Microtubules restrict F-actin polymerization to the immune synapse via GEF-H1 to maintain polarity in lymphocytes

    Judith Pineau, Léa Pinon ... Paolo Pierobon
    Microfluidics and dynamic imaging allow systematic characterization of polarization kinetics in B lymphocytes and highlight the role of microtubules as master regulators of actin polymerization at the immune synapse.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Reconstructing the in vivo dynamics of hematopoietic stem cells from telomere length distributions

    Benjamin Werner, Fabian Beier ... Arne Traulsen
    Telomere length distributions can be used to infer important properties of stem cell proliferation.
    1. Immunology and Inflammation

    Capturing change in clonal composition amongst single mouse germinal centers

    Daniel J Firl, Soren E Degn ... Michael C Carroll
    Repeated interrogation of single germinal centers in vivo reveals a more fluid landscape than expected and unlocks new lines of investigation.
    1. Immunology and Inflammation

    SARS-CoV-2 uses CD4 to infect T helper lymphocytes

    Natalia S Brunetti, Gustavo G Davanzo ... Alessandro S Farias
    The infection of T helper lymphocytes by SARS-CoV-2, mediated via the CD4 molecule, alters cellular function and enhances expression of the anti-inflammatory cytokine IL-10, potentially impairing immune response in individuals with COVID-19.

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