330 results found
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    T cell receptor repertoires of mice and humans are clustered in similarity networks around conserved public CDR3 sequences

    Asaf Madi et al.
    A new perception of the organization of T-cell receptor repertoires in mice and humans, based on high-throughput sequencing and CDR3 sequence similarity, indicates hubs of cross-species public sequences forming evolutionary conserved 'foci of attention' of T cell immunity.
    1. Immunology and Inflammation

    Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses

    Jialong Yang et al.
    Genetic ablation of Raptor and Rictor in mice revealed critical roles of mTORC1 and mTORC2 in T follicular helper cell differentiation and germinal center responses.
    1. Genetics and Genomics

    Point of View: Bioengineering horizon scan 2020

    Luke Kemp et al.
    20 emerging issues in bioengineering that will have profound impacts on society have been identified.
    1. Cell Biology
    2. Computational and Systems Biology

    Science Forum: The Human Cell Atlas

    Aviv Regev et al.
    Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
    1. Immunology and Inflammation

    Innate Like Lymphocytes: Moving at the frontline

    Marco Ataíde, Wolfgang Kastenmüller
    Insight
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    1. Cell Biology
    2. Immunology and Inflammation

    Formin-like 1 mediates effector T cell trafficking to inflammatory sites to enable T cell-mediated autoimmunity

    Scott B Thompson et al.
    Lymphocyte migration and autoimmunity induction rely on Formin-like 1-mediated actin network remodeling to push the lymphocyte nucleus through restrictive endothelial barriers.
    1. Cancer Biology

    MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation

    Seiji Arai et al.
    MARCH5 mediates a pathway driving MCL1 degradation in response to cellular stress, which sensitizes to BH3 mimetic drugs targeting BCLXL and provides a broadly effective therapeutic strategy for solid tumors.
    1. Cell Biology

    ERK3/MAPK6 controls IL-8 production and chemotaxis

    Katarzyna Bogucka et al.
    Understudied atypical MAPK, ERK3 controls epithelial secretome and chemotaxis.
    1. Immunology and Inflammation

    Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells

    Rebeca Jimeno et al.
    The tissue environment shapes the lipid recognition capacity of natural killer T cells.
    1. Immunology and Inflammation

    c-Maf restrains T-bet-driven programming of CCR6-negative group 3 innate lymphoid cells

    Caroline Tizian et al.
    c-Maf is a novel key regulator of the type 3-to-1 conversion of CCR6 ILC3s that controls the functional plasticity of ILC3s by acting as a cell-intrinsic gatekeeper of T-bet expression.

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