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Naïve CD8⁺ T cells are dysregulated during chronic hepatitis C (HCV) infection, and this is reversible after viral clearance.

Asymmetrical expression dictates functional dominance of one STAT5 paralog at cellular and tissue levels despite redundancy at molecular and genomic levels.

The rapid development of immune memory in infancy shapes the composition of T cell defenses throughout the human lifespan.

Functional subsets of helper CD4+ T cells carry TCR repertoires with distinct features that are reproducible across donors and are partially acquired at the level of thymic selection.

The common human HAQ,AQ alleles suppress STING1 gain-of-function mutation-induced chronic STING1 inflammation in mice.

Only three Spike mutations enable murine SARS-CoV-2 infection, which is still strictly ACE2 dependent and causes a COVID-19-like disease in mice with immunopathology-driven lung damage.

Fam49b is a critical regulator of selection process to ensure normal thymocyte development and peripheral T cells survival.

Nebulized dornase alfa endonuclease reduces inflammation, coagulopathy, and the length of hospitalization in individuals with severe COVID-19 pneumonia.

Different etiologies of community-acquired pneumonia evoke both shared and diverging immunological responses.