Quantitative FRET imaging in moving C. elegans shows that stretch-unfolding of twitchin kinase occurs in the active muscle, whereby mechanical activity titrates the signaling pathway of this cytoskeletal kinase.
Topoisomerase IV and the ter-binding protein MatP competitively bind the hinge domain of the Escherichia coli Structural Maintenance of Chromosomes complex, MukB, leading to spatiotemporal regulation of MukBEF-topoisomerase IV activity.
Myogenin promotes centrosome attenuation and establishes the nuclear envelope as the dominant microtubule organization center via the scaffold protein AKAP6, which is required for the recruitment of centrosomal proteins.
Functional analyses of in vitro fertilized, preimplanation human embryos reveal that the first lineage segregation depends on cell polarization signaling that is regulated by Phospholipase C (PLC) activity.
Genetic and biochemical analyses reveal that two stem-cell-specific microRNAs control stem cell fate decisions between pluripotency and differentiation through repressing Ago2, a key component of the microRNA machinery.