Macropinocytosis of the signalling receptor LPAR1, by an actin and CYRI-B-dependent mechanism, impacts on progression and spread of pancreatic cancer in a mouse model.

A lipid mediator lysophosphatidic acid (LPA) derived from fibroblastic reticular cells regulates T-cell movement through the densely packed reticular network in lymph nodes in a manner dependent on the LPA receptor LPA₂-ROCK-myosin II.

TANGO2 emerges as a key regulator of fatty acid metabolism by likely affecting acyl-CoA production and utilization.

Combined cutting-edge technologies discovered a pair of carboxylate transporters that appears evolutionarily different among novel transporters and that is essential for parasite physiology.

siRNA knockdown experiments reveal in detail the signaling pathway that controls cytoskeletal function during cell-in-cell invasion.

Bile acid and it's receptor MRGPRX4, but not TGR5, is one of the ligand-receptor pairs for chronic itch in patients with liver diseases.

PTEN organizes multicellular architecture by non-catalytic scaffolding of spatially localized β-Arrestin1/ARHGAP21/Cdc42 protein complexes to control mitotic spindle orientation, multicellular configuration and lumen formation.

Dysregulated unsaturated fatty acids and saturated fatty acids contribute to bacterial phenotypic resistance to antibiotics.

The metabolic readout of endothelial function in the microvessels-on-a-chip facilitates mechanistic studies and detection of biomarkers for microvascular diseases in a physiological relevant environment.

Metabolomics analysis identified potential neuroactive metabolites, issued from food and microbial fermentation, that are linked to symptoms of depression, anxiety and alcohol craving.