3,731 results found
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Free-energy simulations reveal molecular mechanism for functional switch of a DNA helicase

    Wen Ma et al.
    Integration of structural bioinformatics and free-energy simulations reveals how a helicase switches its function from unwinding to rezipping DNA, during which a key metastable conformation is predicted and verified by single-molecule measurements.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Epigenetic drift of H3K27me3 in aging links glycolysis to healthy longevity in Drosophila

    Zaijun Ma et al.
    Epigenetic drift of H3K27me3 is one of the molecular mechanisms that contribute to aging, and stimulation of glycolysis promotes metabolic health and longevity.
    1. Physics of Living Systems

    Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis

    Lu Ma et al.
    The Munc18-1 protein promotes formation of the t-SNARE complex and the half-zippered SNARE complex, two rate-limiting steps of SNARE assembly, to enhance membrane fusion.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Mitotic fidelity requires transgenerational action of a testis-restricted HP1

    Mia T Levine et al.
    Analysis of a spermiogenesis protein reveals a new chromatin requirement for synchrony between maternal DNA packaged in the egg and sperm-packaged paternal DNA in the first embryonic mitosis in Drosophila melanogaster.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Single-molecule force spectroscopy of protein-membrane interactions

    Lu Ma et al.
    A high-resolution method to quantify interactions between lipid bilayers and single proteins under controlled load is presented and applied to key proteins involved in membrane fusion and formation and maintenance of membrane contact sites.
    1. Cell Biology
    2. Genetics and Genomics

    Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity

    Siming Ma et al.
    Profiling of fibroblasts across mammals captures differences in longevity at the level of global gene expression and metabolite levels and reveals pathways that define these differences.
    1. Neuroscience

    Temporal transitions of spontaneous brain activity

    Zhiwei Ma, Nanyin Zhang
    Analysis of resting-state fMRI data revealed nonrandom temporal transitions between spontaneous brain activity patterns in both awake rats and humans.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    ER retention is imposed by COPII protein sorting and attenuated by 4-phenylbutyrate

    Wenfu Ma et al.
    The COPII coat protein, in association with p24 machinery molecules, actively excludes misfolded and resident proteins from endoplasmic reticulum-derived transport vesicles.
    1. Cell Biology
    2. Genetics and Genomics

    Selections that isolate recombinant mitochondrial genomes in animals

    Hansong Ma, Patrick H O'Farrell
    Recombinant mitochondrial genomes can be selected, traits can be genetically mapped and new genetic combinations can be made.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations

    Xiaochu Ma et al.
    The identification of a single-CD4 bound asymmetric HIV-1 Envelope trimer intermediate provides new mechanistic insights into the activation of Envelope for fusion, and highlights the importance of asymmetry in biology.

Refine your results by:

Type
Research categories